Assessing the new and emerging treatments for atopic dermatitis

Lawrence F. Eichenfield, Sheila F. Friedlander, Eric Simpson, Alan D. Irvine

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The newer and emerging treatments for atopic dermatitis (AD) focus on blockade of inflammatory cytokines, especially those that derive from T helper cell type 2 (TH2) and are associated with a pathway of immunoglobulin E (IgE) sensitization. Among the proinflammatory cytokines that have been identified as promising therapeutic targets are chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2), IgE, thymic stromal lymphopoietin (TSLP), and several monoclonal antibodies that block key cytokine pathways in the innate immune response. Two agents that have been studied in phase III clinical trials are the boronbased phosphodiesterase-4 (PDE-4) inhibitor, crisaborole, and dupilumab, an antibody that inhibits the interleukin-4/IL-13 receptor α chain.

Original languageEnglish (US)
Pages (from-to)92S-96S
JournalSeminars in Cutaneous Medicine and Surgery
Volume35
DOIs
StatePublished - Jun 1 2016

Keywords

  • Atopic dermatitis
  • Crisaborole
  • Dupilumab
  • Interleukin inhibitors
  • Petrolatum
  • Skin barrier

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Dermatology

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