Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus

Carla L. Endres, Eric Bergquam, Michael K. Axthelm, Scott W. Wong

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    Abstract: A plasmid encoding the full‐length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co‐transfection studies were initiated with the infectious proviral clone and a well‐characterized trans‐dominant negative HIV‐1 rev mutant. 1995 Munksgaard

    Original languageEnglish (US)
    Pages (from-to)141-144
    Number of pages4
    JournalJournal of medical primatology
    Volume24
    Issue number3
    DOIs
    StatePublished - May 1995

    Keywords

    • HIV
    • SIV
    • antiviral
    • gene therapy
    • retrovirus
    • transient transfection

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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