Assessing epicardial substrate using intracardiac echocardiography during VT ablation

Rupa Bala, Jian Fang Ren, Mathew D. Hutchinson, Benoit Desjardins, Cory Tschabrunn, Edward P. Gerstenfeld, Rajat Deo, Sanjay Dixit, Fermin C. Garcia, Joshua Cooper, David Lin, Michael P. Riley, Wendy S. Tzou, Ralph Verdino, Andrew E. Epstein, David J. Callans, Francis E. Marchlinski

Research output: Contribution to journalArticle

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Abstract

Background-Intracardiac echocardiography (ICE) has played a limited role in defining the substrate for ventricular tachycardia (VT). The purpose of this study was to assess whether ICE could identify abnormal epicardial substrate in patients with nonischemic cardiomyopathy (NICM) and VT. Methods and Results-We studied 18 patients with NICM and recurrent VT who had abnormal echogenicity identified on ICE imaging. Detailed left ventricular (LV) endocardial and epicardial electroanatomic mapping was performed in all patients. Low-voltage areas (2; minimum-maximum, 2.1-31.7 cm 2) in 9 patients (5 posterolateral LV, 4 perivalvular LV). Detailed epicardial mapping revealed areas of low voltage (39 cm 2; minimum-maximum, 18.5-96.3 cm 2) and abnormal, fractionated electrograms in all 18 patients (15 posterolateral LV, 3 lateral LV). In all patients, the epicardial scar identified by electroanatomic mapping correlated with the echogenic area identified on ICE imaging. ICE imaging identified no areas of increased echogenicity in the control group. Conclusions-ICE imaging identified increased echogenicity in the lateral wall of the LV that correlated to abnormal epicardial substrate. These findings suggest that ICE imaging may be useful to identify epicardial substrate in NICM.

Original languageEnglish (US)
Pages (from-to)667-673
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume4
Issue number5
DOIs
StatePublished - Oct 2011
Externally publishedYes

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Ventricular Tachycardia
Echocardiography
Epicardial Mapping
Cardiomyopathies
Cicatrix
Control Groups

Keywords

  • Catheter ablation
  • Echocardiography
  • Epicardial mapping
  • Imaging
  • Tachycardia ventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Bala, R., Ren, J. F., Hutchinson, M. D., Desjardins, B., Tschabrunn, C., Gerstenfeld, E. P., ... Marchlinski, F. E. (2011). Assessing epicardial substrate using intracardiac echocardiography during VT ablation. Circulation: Arrhythmia and Electrophysiology, 4(5), 667-673. https://doi.org/10.1161/CIRCEP.111.963553

Assessing epicardial substrate using intracardiac echocardiography during VT ablation. / Bala, Rupa; Ren, Jian Fang; Hutchinson, Mathew D.; Desjardins, Benoit; Tschabrunn, Cory; Gerstenfeld, Edward P.; Deo, Rajat; Dixit, Sanjay; Garcia, Fermin C.; Cooper, Joshua; Lin, David; Riley, Michael P.; Tzou, Wendy S.; Verdino, Ralph; Epstein, Andrew E.; Callans, David J.; Marchlinski, Francis E.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 4, No. 5, 10.2011, p. 667-673.

Research output: Contribution to journalArticle

Bala, R, Ren, JF, Hutchinson, MD, Desjardins, B, Tschabrunn, C, Gerstenfeld, EP, Deo, R, Dixit, S, Garcia, FC, Cooper, J, Lin, D, Riley, MP, Tzou, WS, Verdino, R, Epstein, AE, Callans, DJ & Marchlinski, FE 2011, 'Assessing epicardial substrate using intracardiac echocardiography during VT ablation', Circulation: Arrhythmia and Electrophysiology, vol. 4, no. 5, pp. 667-673. https://doi.org/10.1161/CIRCEP.111.963553
Bala, Rupa ; Ren, Jian Fang ; Hutchinson, Mathew D. ; Desjardins, Benoit ; Tschabrunn, Cory ; Gerstenfeld, Edward P. ; Deo, Rajat ; Dixit, Sanjay ; Garcia, Fermin C. ; Cooper, Joshua ; Lin, David ; Riley, Michael P. ; Tzou, Wendy S. ; Verdino, Ralph ; Epstein, Andrew E. ; Callans, David J. ; Marchlinski, Francis E. / Assessing epicardial substrate using intracardiac echocardiography during VT ablation. In: Circulation: Arrhythmia and Electrophysiology. 2011 ; Vol. 4, No. 5. pp. 667-673.
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abstract = "Background-Intracardiac echocardiography (ICE) has played a limited role in defining the substrate for ventricular tachycardia (VT). The purpose of this study was to assess whether ICE could identify abnormal epicardial substrate in patients with nonischemic cardiomyopathy (NICM) and VT. Methods and Results-We studied 18 patients with NICM and recurrent VT who had abnormal echogenicity identified on ICE imaging. Detailed left ventricular (LV) endocardial and epicardial electroanatomic mapping was performed in all patients. Low-voltage areas (2; minimum-maximum, 2.1-31.7 cm 2) in 9 patients (5 posterolateral LV, 4 perivalvular LV). Detailed epicardial mapping revealed areas of low voltage (39 cm 2; minimum-maximum, 18.5-96.3 cm 2) and abnormal, fractionated electrograms in all 18 patients (15 posterolateral LV, 3 lateral LV). In all patients, the epicardial scar identified by electroanatomic mapping correlated with the echogenic area identified on ICE imaging. ICE imaging identified no areas of increased echogenicity in the control group. Conclusions-ICE imaging identified increased echogenicity in the lateral wall of the LV that correlated to abnormal epicardial substrate. These findings suggest that ICE imaging may be useful to identify epicardial substrate in NICM.",
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AU - Tschabrunn, Cory

AU - Gerstenfeld, Edward P.

AU - Deo, Rajat

AU - Dixit, Sanjay

AU - Garcia, Fermin C.

AU - Cooper, Joshua

AU - Lin, David

AU - Riley, Michael P.

AU - Tzou, Wendy S.

AU - Verdino, Ralph

AU - Epstein, Andrew E.

AU - Callans, David J.

AU - Marchlinski, Francis E.

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