Assessing benefits and harms of hormone replacement therapy: Clinical applications

Heidi D. Nelson

    Research output: Contribution to journalShort surveypeer-review

    39 Scopus citations

    Abstract

    An estimated one third of postmenopausal women in the United States use hormone replacement therapy (HRT) to treat symptoms of menopause and prevent chronic conditions. In the context of this widespread use, evidence has been growing about the potential harms of HRT, particularly regarding long-term use. Physicians and patients are often confused about how to use results of studies in individual cases. This article applies the current state of evidence for the benefits and harms of HRT to management decisions in 4 clinical situations. Patient preferences, as well as evidence, are important for these decisions. Benefits and harms need to be readdressed periodically to apply newly published evidence and to reassess emerging risks, comorbidities, and needs of individuals.

    Original languageEnglish (US)
    Pages (from-to)882-884
    Number of pages3
    JournalJAMA
    Volume288
    Issue number7
    DOIs
    StatePublished - Aug 21 2002

    ASJC Scopus subject areas

    • Medicine(all)

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