Assembly of microarrays for genome-wide measurement of DNA copy number

Antoine M. Snijders, Norma Nowak, Richard Segraves, Stephanie Blackwood, Nils Brown, Jeffrey Conroy, Greg Hamilton, Anna Katherine Hindle, Bing Huey, Karen Kimura, Sindy Law, Ken Myambo, Joel Palmer, Bauke Ylstra, Jingzhu Pearl Yue, Joe Gray, Ajay N. Jain, Daniel Pinkel, Donna G. Albertson

Research output: Contribution to journalArticle

732 Citations (Scopus)

Abstract

We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

Original languageEnglish (US)
Pages (from-to)263-264
Number of pages2
JournalNature Genetics
Volume29
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Polyploidy
Human Genome
Diploidy
Clone Cells
Genome
Cell Line
DNA

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Snijders, A. M., Nowak, N., Segraves, R., Blackwood, S., Brown, N., Conroy, J., ... Albertson, D. G. (2001). Assembly of microarrays for genome-wide measurement of DNA copy number. Nature Genetics, 29(3), 263-264. https://doi.org/10.1038/ng754

Assembly of microarrays for genome-wide measurement of DNA copy number. / Snijders, Antoine M.; Nowak, Norma; Segraves, Richard; Blackwood, Stephanie; Brown, Nils; Conroy, Jeffrey; Hamilton, Greg; Hindle, Anna Katherine; Huey, Bing; Kimura, Karen; Law, Sindy; Myambo, Ken; Palmer, Joel; Ylstra, Bauke; Yue, Jingzhu Pearl; Gray, Joe; Jain, Ajay N.; Pinkel, Daniel; Albertson, Donna G.

In: Nature Genetics, Vol. 29, No. 3, 2001, p. 263-264.

Research output: Contribution to journalArticle

Snijders, AM, Nowak, N, Segraves, R, Blackwood, S, Brown, N, Conroy, J, Hamilton, G, Hindle, AK, Huey, B, Kimura, K, Law, S, Myambo, K, Palmer, J, Ylstra, B, Yue, JP, Gray, J, Jain, AN, Pinkel, D & Albertson, DG 2001, 'Assembly of microarrays for genome-wide measurement of DNA copy number', Nature Genetics, vol. 29, no. 3, pp. 263-264. https://doi.org/10.1038/ng754
Snijders AM, Nowak N, Segraves R, Blackwood S, Brown N, Conroy J et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nature Genetics. 2001;29(3):263-264. https://doi.org/10.1038/ng754
Snijders, Antoine M. ; Nowak, Norma ; Segraves, Richard ; Blackwood, Stephanie ; Brown, Nils ; Conroy, Jeffrey ; Hamilton, Greg ; Hindle, Anna Katherine ; Huey, Bing ; Kimura, Karen ; Law, Sindy ; Myambo, Ken ; Palmer, Joel ; Ylstra, Bauke ; Yue, Jingzhu Pearl ; Gray, Joe ; Jain, Ajay N. ; Pinkel, Daniel ; Albertson, Donna G. / Assembly of microarrays for genome-wide measurement of DNA copy number. In: Nature Genetics. 2001 ; Vol. 29, No. 3. pp. 263-264.
@article{2570668b9fa74aeaa98012d4ac9b6750,
title = "Assembly of microarrays for genome-wide measurement of DNA copy number",
abstract = "We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.",
author = "Snijders, {Antoine M.} and Norma Nowak and Richard Segraves and Stephanie Blackwood and Nils Brown and Jeffrey Conroy and Greg Hamilton and Hindle, {Anna Katherine} and Bing Huey and Karen Kimura and Sindy Law and Ken Myambo and Joel Palmer and Bauke Ylstra and Yue, {Jingzhu Pearl} and Joe Gray and Jain, {Ajay N.} and Daniel Pinkel and Albertson, {Donna G.}",
year = "2001",
doi = "10.1038/ng754",
language = "English (US)",
volume = "29",
pages = "263--264",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Assembly of microarrays for genome-wide measurement of DNA copy number

AU - Snijders, Antoine M.

AU - Nowak, Norma

AU - Segraves, Richard

AU - Blackwood, Stephanie

AU - Brown, Nils

AU - Conroy, Jeffrey

AU - Hamilton, Greg

AU - Hindle, Anna Katherine

AU - Huey, Bing

AU - Kimura, Karen

AU - Law, Sindy

AU - Myambo, Ken

AU - Palmer, Joel

AU - Ylstra, Bauke

AU - Yue, Jingzhu Pearl

AU - Gray, Joe

AU - Jain, Ajay N.

AU - Pinkel, Daniel

AU - Albertson, Donna G.

PY - 2001

Y1 - 2001

N2 - We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

AB - We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

UR - http://www.scopus.com/inward/record.url?scp=0035179871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035179871&partnerID=8YFLogxK

U2 - 10.1038/ng754

DO - 10.1038/ng754

M3 - Article

C2 - 11687795

AN - SCOPUS:0035179871

VL - 29

SP - 263

EP - 264

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -