Assembly of microarrays for genome-wide measurement of DNA copy number

Antoine M. Snijders, Norma Nowak, Richard Segraves, Stephanie Blackwood, Nils Brown, Jeffrey Conroy, Greg Hamilton, Anna Katherine Hindle, Bing Huey, Karen Kimura, Sindy Law, Ken Myambo, Joel Palmer, Bauke Ylstra, Jingzhu Pearl Yue, Joe W. Gray, Ajay N. Jain, Daniel Pinkel, Donna G. Albertson

Research output: Contribution to journalArticle

739 Scopus citations

Abstract

We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

Original languageEnglish (US)
Pages (from-to)263-264
Number of pages2
JournalNature genetics
Volume29
Issue number3
DOIs
StatePublished - Dec 10 2001

ASJC Scopus subject areas

  • Genetics

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    Snijders, A. M., Nowak, N., Segraves, R., Blackwood, S., Brown, N., Conroy, J., Hamilton, G., Hindle, A. K., Huey, B., Kimura, K., Law, S., Myambo, K., Palmer, J., Ylstra, B., Yue, J. P., Gray, J. W., Jain, A. N., Pinkel, D., & Albertson, D. G. (2001). Assembly of microarrays for genome-wide measurement of DNA copy number. Nature genetics, 29(3), 263-264. https://doi.org/10.1038/ng754