TY - JOUR
T1 - Assembly and biological role of podosomes and invadopodia
AU - Gimona, Mario
AU - Buccione, Roberto
AU - Courtneidge, Sara A.
AU - Linder, Stefan
N1 - Funding Information:
We are grateful to Dr Elisabeth Genot for critical comments on the manuscript and Dr Steve Winder for allowing us to cite unpublished material. The work was supported in part by grants from the European Union (Marie Curie Excellence Grant 002573 to MG, and LSHC-CT-2004-503049 to RB), from the National Cancer Institute (to SAC), from the August-Lenz Stiftung (Germany) and Deutsche Forschungsgemeinschaft (SFB 413 to SL), and from the Italian Association for Cancer Research (AIRC, Milano, Italy) and the Fondazione Cassa di Risparmio della Provincia di Teramo (to RB).
PY - 2008/4
Y1 - 2008/4
N2 - Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
AB - Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
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U2 - 10.1016/j.ceb.2008.01.005
DO - 10.1016/j.ceb.2008.01.005
M3 - Review article
C2 - 18337078
AN - SCOPUS:41549161073
VL - 20
SP - 235
EP - 241
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 2
ER -