Assembly and biological role of podosomes and invadopodia

Mario Gimona, Roberto Buccione, Sara Courtneidge, Stefan Linder

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume20
Issue number2
DOIs
StatePublished - Apr 2008
Externally publishedYes

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Physiological Phenomena
Pathologic Processes
Cellular Structures
Cytoskeleton
Actin Cytoskeleton
Wound Healing
Cell Movement
Extracellular Matrix
Actins
Immune System
Peptide Hydrolases
Pathology
Neoplasm Metastasis
Neoplasms
Podosomes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Assembly and biological role of podosomes and invadopodia. / Gimona, Mario; Buccione, Roberto; Courtneidge, Sara; Linder, Stefan.

In: Current Opinion in Cell Biology, Vol. 20, No. 2, 04.2008, p. 235-241.

Research output: Contribution to journalArticle

Gimona, Mario ; Buccione, Roberto ; Courtneidge, Sara ; Linder, Stefan. / Assembly and biological role of podosomes and invadopodia. In: Current Opinion in Cell Biology. 2008 ; Vol. 20, No. 2. pp. 235-241.
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