Abstract
Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-241 |
| Number of pages | 7 |
| Journal | Current Opinion in Cell Biology |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Assembly and biological role of podosomes and invadopodia. / Gimona, Mario; Buccione, Roberto; Courtneidge, Sara; Linder, Stefan.
In: Current Opinion in Cell Biology, Vol. 20, No. 2, 04.2008, p. 235-241.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assembly and biological role of podosomes and invadopodia
AU - Gimona, Mario
AU - Buccione, Roberto
AU - Courtneidge, Sara
AU - Linder, Stefan
PY - 2008/4
Y1 - 2008/4
N2 - Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
AB - Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
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U2 - 10.1016/j.ceb.2008.01.005
DO - 10.1016/j.ceb.2008.01.005
M3 - Article
VL - 20
SP - 235
EP - 241
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 2
ER -