Abstract
This narrative review appraises the human and animal studies implicating ascorbic acid (AA) in normal cognitive function and Alzheimer's disease. A research framework for how nutrition affects brain aging is proposed with emphasis on AA intake, status, metabolism, and transport into brain tissue. A final synopsis highlights areas for future research regarding AA nourishment and healthy brain aging.
Original language | English (US) |
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Pages (from-to) | 114-122 |
Number of pages | 9 |
Journal | BioFactors |
Volume | 38 |
Issue number | 2 |
DOIs | |
State | Published - Mar 2012 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Ascorbic acid
- Blood-CSF barrier
- Blood-brain barrier
- CSF
- Choroid plexus
- Cognitive function
- Dementia
- Plasma
- SVCT
- Vitamin C
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Clinical Biochemistry