Ascorbic acid, cognitive function, and Alzheimer's disease: A current review and future direction

Gene L. Bowman

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

This narrative review appraises the human and animal studies implicating ascorbic acid (AA) in normal cognitive function and Alzheimer's disease. A research framework for how nutrition affects brain aging is proposed with emphasis on AA intake, status, metabolism, and transport into brain tissue. A final synopsis highlights areas for future research regarding AA nourishment and healthy brain aging.

Original languageEnglish (US)
Pages (from-to)114-122
Number of pages9
JournalBioFactors
Volume38
Issue number2
DOIs
StatePublished - Mar 2012

Keywords

  • Alzheimer's disease
  • Ascorbic acid
  • Blood-CSF barrier
  • Blood-brain barrier
  • CSF
  • Choroid plexus
  • Cognitive function
  • Dementia
  • Plasma
  • SVCT
  • Vitamin C

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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