Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation

Michael Y. Shapira, Igor B. Resnick, Sunwen Chou, Avidan U. Neumann, Nell S. Lurain, Thomas Stamminger, Orit Caplan, Niveen Saleh, Thomas Efferth, Manfred Marschall, Dana G. Wolf

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7-2.1-log reduction in viral load by treatment day 7, with a viral half-life of 0.9-1.9 days, indicating a highly effective block in viral replication.

Original languageEnglish (US)
Pages (from-to)1455-1457
Number of pages3
JournalClinical Infectious Diseases
Volume46
Issue number9
DOIs
StatePublished - May 1 2008

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Hematopoietic Stem Cell Transplantation
Cytomegalovirus Infections
Antiviral Agents
Pharmaceutical Preparations
Foscarnet
Ganciclovir
DNA-Directed DNA Polymerase
Viral Load
Half-Life
Stem Cells
Therapeutics
Transplants
Mutation
artesunate

ASJC Scopus subject areas

  • Immunology

Cite this

Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. / Shapira, Michael Y.; Resnick, Igor B.; Chou, Sunwen; Neumann, Avidan U.; Lurain, Nell S.; Stamminger, Thomas; Caplan, Orit; Saleh, Niveen; Efferth, Thomas; Marschall, Manfred; Wolf, Dana G.

In: Clinical Infectious Diseases, Vol. 46, No. 9, 01.05.2008, p. 1455-1457.

Research output: Contribution to journalArticle

Shapira, MY, Resnick, IB, Chou, S, Neumann, AU, Lurain, NS, Stamminger, T, Caplan, O, Saleh, N, Efferth, T, Marschall, M & Wolf, DG 2008, 'Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation', Clinical Infectious Diseases, vol. 46, no. 9, pp. 1455-1457. https://doi.org/10.1086/587106
Shapira, Michael Y. ; Resnick, Igor B. ; Chou, Sunwen ; Neumann, Avidan U. ; Lurain, Nell S. ; Stamminger, Thomas ; Caplan, Orit ; Saleh, Niveen ; Efferth, Thomas ; Marschall, Manfred ; Wolf, Dana G. / Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. In: Clinical Infectious Diseases. 2008 ; Vol. 46, No. 9. pp. 1455-1457.
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