Arterial pressure after chronic reductions in suprarenal aortic flow in fetal lambs

D. F. Anderson, C. M. Parks, J. J. Faber

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    Experiments were performed on 13 fetal lambs of 126 days gestational age. Seven days after surgery, suprarenal aortic blood flow was reduced to 70% of control with an inflatable occluder for a period of at least 4 days. This produced an almost constant aortic pressure difference of 35 mmHg across the occluder. Plasma renin activity (PRA) rose in the next hour from 6 to 42 ng·ml-1·h-1 (P < 0.01) but decreased to a level that was statistically insignificantly above normal by the next day. PRA as a function of lower body arterial blood pressure showed rapid adaptation. Upper body arterial blood pressure was statistically significantly elevated by 5 mmHg within 5 min and continued to rise while plasma renin activity was falling. Femoral artery blood pressure dropped immediately but returned to near normal within 1 h and remained there. The long-term upper body hypertension was irreversible with a 30-min infusion of saralasin. Subrenal aortic flow reduction caused none of these changes. We conclude that the fetal kidneys can regulate arterial blood pressure upward but that the long-term effect does not depend solely on a direct vasoconstrictive action of angiotensin.

    Original languageEnglish (US)
    Pages (from-to)22/4
    JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
    Volume253
    Issue number4
    StatePublished - Dec 1 1987

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

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