Arterial baroreceptor resetting

Contributions of chronic and acute processes

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Pressure threshold (Pth) and suprathreshold pressure sensitivity (Sth) are important measures of the pressure-discharge characteristics of arterial baroreceptors. An in vitro preparation of the rat aortic arch-aortic nerve has been used to assess the influence of extracellular ion concentration, distensibility, smooth muscle activation and rapid resetting on single fibre baroreceptor discharge. Changes in extracellular cations alter Pth and Sth in a reciprocal manner, suggesting that these two properties share common excitatory mechanisms probably at the level of membrane ion conductance channels. During normal development and ageing in normotensive rats, Pth and blood pressure are fairly constant even during periods of greatly changing aortic distensibility. Sth increases progressively to maturity and then decreases somewhat with advanced age. During hypertension, changes in distensibility in spontaneously hypertensive rats do not account for changes in Pth and Sth. The capacity of arterial baroreceptors to rapidly reset during acute changes in the conditioning mean arterial pressure is not altered by chronic resetting, decreases in distensibility or by differences in the initial Pth or Sth of individual baroreceptors. Within the maximal physiological or pathophysiological range, the prevailing or conditioning mean arterial pressure appears to be the most modulator of arterial baroreceptor discharge.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalClinical and Experimental Pharmacology and Physiology
Volume16
Issue numberSUPPL. 15
StatePublished - 1989
Externally publishedYes

Fingerprint

Pressoreceptors
Pressure
Arterial Pressure
Inbred SHR Rats
Thoracic Aorta
Ion Channels
Smooth Muscle
Cations
Ions
Blood Pressure
Hypertension
Membranes

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

Cite this

Arterial baroreceptor resetting : Contributions of chronic and acute processes. / Andresen, Michael; Yang, M.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 16, No. SUPPL. 15, 1989, p. 19-30.

Research output: Contribution to journalArticle

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