Arrow encodes an LDL-receptor-related protein essential for Wingless signalling

Marcel Wehrli, Scott T. Dougan, Kim Caldwell, Louise O'Keefe, Stephanie Schwartz, Dallt Valzel-Ohayon, Eyal Schejter, Andrew Tomlinson, Stephen DiNardo

Research output: Contribution to journalArticle

661 Scopus citations

Abstract

The Wnt family of secreted molecules functions in cell-fate determination and morphogenesis during development in both vertebrates and invertebrates (reviewed in ref. 1). Drosophila Wingless is a founding member of this family, and many components of its signal transduction cascade have been identified, induding the Frizzled class of receptor. But the mechanism by which the Wingless signal is received and transduced across the membrane is not completely understood. Here we describe a gene that is necessary for all Wingless signalling events in Drosophila. We show that arrow gene function is essential in cells receiving Wingless input and that it acts upstream of Dishevelled. arrow encodes a single-pass transmembrane protein, indicating that it may be part of a receptor complex with Frizzled class proteins. Arrow is a low-density lipoprotein (LDL)-receptor-related protein (LRP), strikingly homologous to murine and human LRP5 and LRP6. Thus, our data suggests a new and conserved function for this LRP subfamily in Wingless/Wnt signal reception.

Original languageEnglish (US)
Pages (from-to)527-530
Number of pages4
JournalNature
Volume407
Issue number6803
DOIs
StatePublished - Sep 28 2000

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Arrow encodes an LDL-receptor-related protein essential for Wingless signalling'. Together they form a unique fingerprint.

  • Cite this

    Wehrli, M., Dougan, S. T., Caldwell, K., O'Keefe, L., Schwartz, S., Valzel-Ohayon, D., Schejter, E., Tomlinson, A., & DiNardo, S. (2000). Arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature, 407(6803), 527-530. https://doi.org/10.1038/35035110