Arrhythmia burden in adults with surgically repaired tetralogy of fallot: A multi-institutional study

Paul Khairy, Jamil Aboulhosn, Michelle Z. Gurvitz, Alexander R. Opotowsky, François Pierre Mongeon, Joseph Kay, Anne Marie Valente, Michael G. Earing, George Lui, Deborah R. Gersony, Stephen Cook, Jennifer Grando Ting, Michelle J. Nickolaus, Gary Webb, Michael J. Landzberg, Craig Broberg

    Research output: Contribution to journalArticle

    270 Citations (Scopus)

    Abstract

    Background: The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. Methods and Results: The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralogy of Fallot, to characterize age-related trends, and to identify associated factors. A total of 556 patients, 54.0% female, 36.8±12.0 years of age were recruited from 11 centers. Overall, 43.3% had a sustained arrhythmia or arrhythmia intervention. Prevalence of atrial tachyarrhythmias was 20.1%. Factors associated with intraatrial reentrant tachycardia in multivariable analyses were right atrial enlargement (odds ratio [OR], 6.2; 95% confidence interval [CI], 2.8 to 13.6), hypertension (OR, 2.3; 95% CI, 1.1 to 4.6), and number of cardiac surgeries (OR, 1.4; 95% CI, 1.2 to 1.6). Older age (OR, 1.09 per year; 95% CI, 1.05 to 1.12), lower left ventricular ejection fraction (OR, 0.93 per unit; 95% CI, 0.89 to 0.96), left atrial dilation (OR, 3.2; 95% CI, 1.5 to 6.8), and number of cardiac surgeries (OR, 1.5; 95% CI, 1.2 to 1.9) were jointly associated with atrial fibrillation. Ventricular arrhythmias were prevalent in 14.6% and jointly associated with number of cardiac surgeries (OR, 1.3; 95% CI, 1.1 to 1.6), QRS duration (OR, 1.02 per 1 ms; 95% CI, 1.01 to 1.03), and left ventricular diastolic dysfunction (OR, 3.3; 95% CI, 1.5 to 7.1). Prevalence of atrial fibrillation and ventricular arrhythmias markedly increased after 45 years of age. Conclusions: The arrhythmia burden in adults with tetralogy of Fallot is considerable, with various subtypes characterized by different profiles. Atrial fibrillation and ventricular arrhythmias appear to be influenced more by left-than right-sided heart disease.

    Original languageEnglish (US)
    Pages (from-to)868-875
    Number of pages8
    JournalCirculation
    Volume122
    Issue number9
    DOIs
    StatePublished - Aug 31 2010

    Fingerprint

    Tetralogy of Fallot
    Cardiac Arrhythmias
    Odds Ratio
    Confidence Intervals
    Atrial Fibrillation
    Thoracic Surgery
    Tachycardia
    Left Ventricular Dysfunction
    Cardiology
    Stroke Volume
    Dilatation
    Heart Diseases
    Cross-Sectional Studies
    Hypertension

    Keywords

    • arrhythmias
    • atrial flutter
    • cardiac
    • tachycardia
    • tetralogy of Fallot

    ASJC Scopus subject areas

    • Physiology (medical)
    • Cardiology and Cardiovascular Medicine
    • Medicine(all)

    Cite this

    Arrhythmia burden in adults with surgically repaired tetralogy of fallot : A multi-institutional study. / Khairy, Paul; Aboulhosn, Jamil; Gurvitz, Michelle Z.; Opotowsky, Alexander R.; Mongeon, François Pierre; Kay, Joseph; Valente, Anne Marie; Earing, Michael G.; Lui, George; Gersony, Deborah R.; Cook, Stephen; Grando Ting, Jennifer; Nickolaus, Michelle J.; Webb, Gary; Landzberg, Michael J.; Broberg, Craig.

    In: Circulation, Vol. 122, No. 9, 31.08.2010, p. 868-875.

    Research output: Contribution to journalArticle

    Khairy, P, Aboulhosn, J, Gurvitz, MZ, Opotowsky, AR, Mongeon, FP, Kay, J, Valente, AM, Earing, MG, Lui, G, Gersony, DR, Cook, S, Grando Ting, J, Nickolaus, MJ, Webb, G, Landzberg, MJ & Broberg, C 2010, 'Arrhythmia burden in adults with surgically repaired tetralogy of fallot: A multi-institutional study', Circulation, vol. 122, no. 9, pp. 868-875. https://doi.org/10.1161/CIRCULATIONAHA.109.928481
    Khairy, Paul ; Aboulhosn, Jamil ; Gurvitz, Michelle Z. ; Opotowsky, Alexander R. ; Mongeon, François Pierre ; Kay, Joseph ; Valente, Anne Marie ; Earing, Michael G. ; Lui, George ; Gersony, Deborah R. ; Cook, Stephen ; Grando Ting, Jennifer ; Nickolaus, Michelle J. ; Webb, Gary ; Landzberg, Michael J. ; Broberg, Craig. / Arrhythmia burden in adults with surgically repaired tetralogy of fallot : A multi-institutional study. In: Circulation. 2010 ; Vol. 122, No. 9. pp. 868-875.
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    title = "Arrhythmia burden in adults with surgically repaired tetralogy of fallot: A multi-institutional study",
    abstract = "Background: The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. Methods and Results: The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralogy of Fallot, to characterize age-related trends, and to identify associated factors. A total of 556 patients, 54.0{\%} female, 36.8±12.0 years of age were recruited from 11 centers. Overall, 43.3{\%} had a sustained arrhythmia or arrhythmia intervention. Prevalence of atrial tachyarrhythmias was 20.1{\%}. Factors associated with intraatrial reentrant tachycardia in multivariable analyses were right atrial enlargement (odds ratio [OR], 6.2; 95{\%} confidence interval [CI], 2.8 to 13.6), hypertension (OR, 2.3; 95{\%} CI, 1.1 to 4.6), and number of cardiac surgeries (OR, 1.4; 95{\%} CI, 1.2 to 1.6). Older age (OR, 1.09 per year; 95{\%} CI, 1.05 to 1.12), lower left ventricular ejection fraction (OR, 0.93 per unit; 95{\%} CI, 0.89 to 0.96), left atrial dilation (OR, 3.2; 95{\%} CI, 1.5 to 6.8), and number of cardiac surgeries (OR, 1.5; 95{\%} CI, 1.2 to 1.9) were jointly associated with atrial fibrillation. Ventricular arrhythmias were prevalent in 14.6{\%} and jointly associated with number of cardiac surgeries (OR, 1.3; 95{\%} CI, 1.1 to 1.6), QRS duration (OR, 1.02 per 1 ms; 95{\%} CI, 1.01 to 1.03), and left ventricular diastolic dysfunction (OR, 3.3; 95{\%} CI, 1.5 to 7.1). Prevalence of atrial fibrillation and ventricular arrhythmias markedly increased after 45 years of age. Conclusions: The arrhythmia burden in adults with tetralogy of Fallot is considerable, with various subtypes characterized by different profiles. Atrial fibrillation and ventricular arrhythmias appear to be influenced more by left-than right-sided heart disease.",
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    author = "Paul Khairy and Jamil Aboulhosn and Gurvitz, {Michelle Z.} and Opotowsky, {Alexander R.} and Mongeon, {Fran{\cc}ois Pierre} and Joseph Kay and Valente, {Anne Marie} and Earing, {Michael G.} and George Lui and Gersony, {Deborah R.} and Stephen Cook and {Grando Ting}, Jennifer and Nickolaus, {Michelle J.} and Gary Webb and Landzberg, {Michael J.} and Craig Broberg",
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    TY - JOUR

    T1 - Arrhythmia burden in adults with surgically repaired tetralogy of fallot

    T2 - A multi-institutional study

    AU - Khairy, Paul

    AU - Aboulhosn, Jamil

    AU - Gurvitz, Michelle Z.

    AU - Opotowsky, Alexander R.

    AU - Mongeon, François Pierre

    AU - Kay, Joseph

    AU - Valente, Anne Marie

    AU - Earing, Michael G.

    AU - Lui, George

    AU - Gersony, Deborah R.

    AU - Cook, Stephen

    AU - Grando Ting, Jennifer

    AU - Nickolaus, Michelle J.

    AU - Webb, Gary

    AU - Landzberg, Michael J.

    AU - Broberg, Craig

    PY - 2010/8/31

    Y1 - 2010/8/31

    N2 - Background: The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. Methods and Results: The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralogy of Fallot, to characterize age-related trends, and to identify associated factors. A total of 556 patients, 54.0% female, 36.8±12.0 years of age were recruited from 11 centers. Overall, 43.3% had a sustained arrhythmia or arrhythmia intervention. Prevalence of atrial tachyarrhythmias was 20.1%. Factors associated with intraatrial reentrant tachycardia in multivariable analyses were right atrial enlargement (odds ratio [OR], 6.2; 95% confidence interval [CI], 2.8 to 13.6), hypertension (OR, 2.3; 95% CI, 1.1 to 4.6), and number of cardiac surgeries (OR, 1.4; 95% CI, 1.2 to 1.6). Older age (OR, 1.09 per year; 95% CI, 1.05 to 1.12), lower left ventricular ejection fraction (OR, 0.93 per unit; 95% CI, 0.89 to 0.96), left atrial dilation (OR, 3.2; 95% CI, 1.5 to 6.8), and number of cardiac surgeries (OR, 1.5; 95% CI, 1.2 to 1.9) were jointly associated with atrial fibrillation. Ventricular arrhythmias were prevalent in 14.6% and jointly associated with number of cardiac surgeries (OR, 1.3; 95% CI, 1.1 to 1.6), QRS duration (OR, 1.02 per 1 ms; 95% CI, 1.01 to 1.03), and left ventricular diastolic dysfunction (OR, 3.3; 95% CI, 1.5 to 7.1). Prevalence of atrial fibrillation and ventricular arrhythmias markedly increased after 45 years of age. Conclusions: The arrhythmia burden in adults with tetralogy of Fallot is considerable, with various subtypes characterized by different profiles. Atrial fibrillation and ventricular arrhythmias appear to be influenced more by left-than right-sided heart disease.

    AB - Background: The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. Methods and Results: The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralogy of Fallot, to characterize age-related trends, and to identify associated factors. A total of 556 patients, 54.0% female, 36.8±12.0 years of age were recruited from 11 centers. Overall, 43.3% had a sustained arrhythmia or arrhythmia intervention. Prevalence of atrial tachyarrhythmias was 20.1%. Factors associated with intraatrial reentrant tachycardia in multivariable analyses were right atrial enlargement (odds ratio [OR], 6.2; 95% confidence interval [CI], 2.8 to 13.6), hypertension (OR, 2.3; 95% CI, 1.1 to 4.6), and number of cardiac surgeries (OR, 1.4; 95% CI, 1.2 to 1.6). Older age (OR, 1.09 per year; 95% CI, 1.05 to 1.12), lower left ventricular ejection fraction (OR, 0.93 per unit; 95% CI, 0.89 to 0.96), left atrial dilation (OR, 3.2; 95% CI, 1.5 to 6.8), and number of cardiac surgeries (OR, 1.5; 95% CI, 1.2 to 1.9) were jointly associated with atrial fibrillation. Ventricular arrhythmias were prevalent in 14.6% and jointly associated with number of cardiac surgeries (OR, 1.3; 95% CI, 1.1 to 1.6), QRS duration (OR, 1.02 per 1 ms; 95% CI, 1.01 to 1.03), and left ventricular diastolic dysfunction (OR, 3.3; 95% CI, 1.5 to 7.1). Prevalence of atrial fibrillation and ventricular arrhythmias markedly increased after 45 years of age. Conclusions: The arrhythmia burden in adults with tetralogy of Fallot is considerable, with various subtypes characterized by different profiles. Atrial fibrillation and ventricular arrhythmias appear to be influenced more by left-than right-sided heart disease.

    KW - arrhythmias

    KW - atrial flutter

    KW - cardiac

    KW - tachycardia

    KW - tetralogy of Fallot

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