Array-based DNA methylation profiling in follicular lymphoma

C. O'Riain, D. M. O'Shea, Y. Yang, R. Le Dieu, J. G. Gribben, K. Summers, J. Yeboah-Afari, L. Bhaw-Rosun, C. Fleischmann, C. A. Mein, T. Crook, P. Smith, G. Kelly, A. Rosenwald, G. Ott, E. Campo, L. M. Rimsza, E. B. Smeland, W. C. Chan, N. JohnsonR. D. Gascoyne, S. Reimer, Rita Braziel, G. W. Wright, L. M. Staudt, T. A. Lister, J. Fitzgibbon

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples and purified B and T cells from two FL cases. Methylation values allowed separation of untreated FL samples from controls with one exception, based primarily on tumour-specific gains of methylation typically occurring within CpG islands. Genes that are targets for epigenetic repression in stem cells by Polycomb Repressor Complex 2 were significantly over-represented among hypermethylated genes. Methylation profiles were conserved in sequential FL and t-FL biopsies, suggesting that widespread methylation represents an early event in lymphomagenesis and may not contribute substantially to transformation. A significant (P

Original languageEnglish (US)
Pages (from-to)1858-1866
Number of pages9
JournalLeukemia
Volume23
Issue number10
DOIs
StatePublished - 2009

Fingerprint

Follicular Lymphoma
DNA Fingerprinting
DNA Methylation
Methylation
Epigenetic Repression
CpG Islands
Genes
B-Lymphocytes
Stem Cells
T-Lymphocytes
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

Cite this

O'Riain, C., O'Shea, D. M., Yang, Y., Le Dieu, R., Gribben, J. G., Summers, K., ... Fitzgibbon, J. (2009). Array-based DNA methylation profiling in follicular lymphoma. Leukemia, 23(10), 1858-1866. https://doi.org/10.1038/leu.2009.114

Array-based DNA methylation profiling in follicular lymphoma. / O'Riain, C.; O'Shea, D. M.; Yang, Y.; Le Dieu, R.; Gribben, J. G.; Summers, K.; Yeboah-Afari, J.; Bhaw-Rosun, L.; Fleischmann, C.; Mein, C. A.; Crook, T.; Smith, P.; Kelly, G.; Rosenwald, A.; Ott, G.; Campo, E.; Rimsza, L. M.; Smeland, E. B.; Chan, W. C.; Johnson, N.; Gascoyne, R. D.; Reimer, S.; Braziel, Rita; Wright, G. W.; Staudt, L. M.; Lister, T. A.; Fitzgibbon, J.

In: Leukemia, Vol. 23, No. 10, 2009, p. 1858-1866.

Research output: Contribution to journalArticle

O'Riain, C, O'Shea, DM, Yang, Y, Le Dieu, R, Gribben, JG, Summers, K, Yeboah-Afari, J, Bhaw-Rosun, L, Fleischmann, C, Mein, CA, Crook, T, Smith, P, Kelly, G, Rosenwald, A, Ott, G, Campo, E, Rimsza, LM, Smeland, EB, Chan, WC, Johnson, N, Gascoyne, RD, Reimer, S, Braziel, R, Wright, GW, Staudt, LM, Lister, TA & Fitzgibbon, J 2009, 'Array-based DNA methylation profiling in follicular lymphoma', Leukemia, vol. 23, no. 10, pp. 1858-1866. https://doi.org/10.1038/leu.2009.114
O'Riain C, O'Shea DM, Yang Y, Le Dieu R, Gribben JG, Summers K et al. Array-based DNA methylation profiling in follicular lymphoma. Leukemia. 2009;23(10):1858-1866. https://doi.org/10.1038/leu.2009.114
O'Riain, C. ; O'Shea, D. M. ; Yang, Y. ; Le Dieu, R. ; Gribben, J. G. ; Summers, K. ; Yeboah-Afari, J. ; Bhaw-Rosun, L. ; Fleischmann, C. ; Mein, C. A. ; Crook, T. ; Smith, P. ; Kelly, G. ; Rosenwald, A. ; Ott, G. ; Campo, E. ; Rimsza, L. M. ; Smeland, E. B. ; Chan, W. C. ; Johnson, N. ; Gascoyne, R. D. ; Reimer, S. ; Braziel, Rita ; Wright, G. W. ; Staudt, L. M. ; Lister, T. A. ; Fitzgibbon, J. / Array-based DNA methylation profiling in follicular lymphoma. In: Leukemia. 2009 ; Vol. 23, No. 10. pp. 1858-1866.
@article{a5af4a09e1d54535b4660154efe71b87,
title = "Array-based DNA methylation profiling in follicular lymphoma",
abstract = "Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples and purified B and T cells from two FL cases. Methylation values allowed separation of untreated FL samples from controls with one exception, based primarily on tumour-specific gains of methylation typically occurring within CpG islands. Genes that are targets for epigenetic repression in stem cells by Polycomb Repressor Complex 2 were significantly over-represented among hypermethylated genes. Methylation profiles were conserved in sequential FL and t-FL biopsies, suggesting that widespread methylation represents an early event in lymphomagenesis and may not contribute substantially to transformation. A significant (P",
author = "C. O'Riain and O'Shea, {D. M.} and Y. Yang and {Le Dieu}, R. and Gribben, {J. G.} and K. Summers and J. Yeboah-Afari and L. Bhaw-Rosun and C. Fleischmann and Mein, {C. A.} and T. Crook and P. Smith and G. Kelly and A. Rosenwald and G. Ott and E. Campo and Rimsza, {L. M.} and Smeland, {E. B.} and Chan, {W. C.} and N. Johnson and Gascoyne, {R. D.} and S. Reimer and Rita Braziel and Wright, {G. W.} and Staudt, {L. M.} and Lister, {T. A.} and J. Fitzgibbon",
year = "2009",
doi = "10.1038/leu.2009.114",
language = "English (US)",
volume = "23",
pages = "1858--1866",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Array-based DNA methylation profiling in follicular lymphoma

AU - O'Riain, C.

AU - O'Shea, D. M.

AU - Yang, Y.

AU - Le Dieu, R.

AU - Gribben, J. G.

AU - Summers, K.

AU - Yeboah-Afari, J.

AU - Bhaw-Rosun, L.

AU - Fleischmann, C.

AU - Mein, C. A.

AU - Crook, T.

AU - Smith, P.

AU - Kelly, G.

AU - Rosenwald, A.

AU - Ott, G.

AU - Campo, E.

AU - Rimsza, L. M.

AU - Smeland, E. B.

AU - Chan, W. C.

AU - Johnson, N.

AU - Gascoyne, R. D.

AU - Reimer, S.

AU - Braziel, Rita

AU - Wright, G. W.

AU - Staudt, L. M.

AU - Lister, T. A.

AU - Fitzgibbon, J.

PY - 2009

Y1 - 2009

N2 - Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples and purified B and T cells from two FL cases. Methylation values allowed separation of untreated FL samples from controls with one exception, based primarily on tumour-specific gains of methylation typically occurring within CpG islands. Genes that are targets for epigenetic repression in stem cells by Polycomb Repressor Complex 2 were significantly over-represented among hypermethylated genes. Methylation profiles were conserved in sequential FL and t-FL biopsies, suggesting that widespread methylation represents an early event in lymphomagenesis and may not contribute substantially to transformation. A significant (P

AB - Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples and purified B and T cells from two FL cases. Methylation values allowed separation of untreated FL samples from controls with one exception, based primarily on tumour-specific gains of methylation typically occurring within CpG islands. Genes that are targets for epigenetic repression in stem cells by Polycomb Repressor Complex 2 were significantly over-represented among hypermethylated genes. Methylation profiles were conserved in sequential FL and t-FL biopsies, suggesting that widespread methylation represents an early event in lymphomagenesis and may not contribute substantially to transformation. A significant (P

UR - http://www.scopus.com/inward/record.url?scp=70350103292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350103292&partnerID=8YFLogxK

U2 - 10.1038/leu.2009.114

DO - 10.1038/leu.2009.114

M3 - Article

C2 - 19587707

AN - SCOPUS:70350103292

VL - 23

SP - 1858

EP - 1866

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 10

ER -