TY - JOUR
T1 - Arginine in the critical care setting
AU - Zhou, Minhao
AU - Martindale, Robert G.
PY - 2007/6
Y1 - 2007/6
N2 - Arginine is a nonessential amino acid in the normal physiological state that becomes conditionally essential during periods of hypermetabolic stress. Recent literature supports the hypothesis that arginine plays an important role in the intermediary metabolism of the critically ill patient. Current critical care literature is conflicting on arginine use in the clinical setting, with some proposing it as a panacea, whereas others report it as poison. Multiple individual reports and at least 5 major meta-analyses using combinations of immune-modulating nutrients have reported mostly beneficial results, but few have evaluated the effects of arginine when given as a single supplemental nutrient. This review attempts to objectively analyze the literature and evaluate the potential role of arginine in the critical care setting.
AB - Arginine is a nonessential amino acid in the normal physiological state that becomes conditionally essential during periods of hypermetabolic stress. Recent literature supports the hypothesis that arginine plays an important role in the intermediary metabolism of the critically ill patient. Current critical care literature is conflicting on arginine use in the clinical setting, with some proposing it as a panacea, whereas others report it as poison. Multiple individual reports and at least 5 major meta-analyses using combinations of immune-modulating nutrients have reported mostly beneficial results, but few have evaluated the effects of arginine when given as a single supplemental nutrient. This review attempts to objectively analyze the literature and evaluate the potential role of arginine in the critical care setting.
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U2 - 10.1093/jn/137.6.1687s
DO - 10.1093/jn/137.6.1687s
M3 - Article
C2 - 17513448
AN - SCOPUS:34249800928
SN - 0022-3166
VL - 137
SP - 1687S-1692S
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 6
ER -