Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys

Li Min Chen, Robert M. Friedman, Anna Roe

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

While functional imaging studies in humans have consistently reported activation of primary somatosensory cortex (SI) with painful stimuli, the specific roles of subdivisions of areas 3a, 3b, and 1 within SI during pain perception are largely unknown, particularly in the representation of mechanical evoked pain. In this study, we investigated how modality, location, and intensity of nociceptive stimuli are represented within SI by using high-spatial resolution optical imaging of intrinsic signals in Pentothal-anesthetized squirrel monkeys. Perceptually comparable mechanical nociceptive and innocuous tactile stimuli were delivered by indenting the glabrous skin of the distal finger pads with 0.2 and 2 mm diameter probes, respectively. Within each of areas 3a, 3b, and 1, activations to mechanical nociceptive stimulation of individual distal finger pads were spatially distinct and somatotopically organized. We observed differential cortical activation patterns. Areas 3a, 3b, and 1 were all activated during mechanical nociceptive stimulation and were modulated by nociceptive stimulus intensity. However, with innocuous tactile stimulation, mainly areas 3b and 1 exhibited response modulation with different levels of stimulation. In summary, mechanical nociceptive inputs are area-specific and topographically represented within SI. We propose that all areas of SI are implicated in encoding the features of mechanical nociception, where areas 3a and 3b are distinctively involved in coding nociceptive and pressure sensation components of stimulation.

Original languageEnglish (US)
Pages (from-to)258-268
Number of pages11
JournalPain
Volume141
Issue number3
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

Saimiri
Somatosensory Cortex
Touch
Fingers
Pain Perception
Nociception
Thiopental
Optical Imaging
Pressure
Pain
Skin

Keywords

  • Digit
  • Intrinsic optical imaging
  • Mechanical nociception
  • Primary somatosensory cortex
  • Primate
  • Touch

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys. / Chen, Li Min; Friedman, Robert M.; Roe, Anna.

In: Pain, Vol. 141, No. 3, 02.2009, p. 258-268.

Research output: Contribution to journalArticle

Chen, Li Min ; Friedman, Robert M. ; Roe, Anna. / Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys. In: Pain. 2009 ; Vol. 141, No. 3. pp. 258-268.
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