Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database

Ryan Kopp, Sean P. Stroup, Florian R. Schroeck, Stephen J. Freedland, Frederick Millard, Martha K. Terris, William J. Aronson, Joseph C. Presti, Christopher Amling, Christopher J. Kane

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: Patients question whether multiple biopsy sessions cause worse prostate cancer outcomes. Therefore, we investigated whether there is an association between the number of prior biopsy sessions and biochemical recurrence after radical prostatectomy. Materials and Methods: Men in the SEARCH (Shared Equal Access Regional Cancer Hospital) database who underwent radical prostatectomy between 1988 and 2010 after a known number of prior biopsies were included in the analysis. Number of biopsy sessions (range 1 to 8) was examined as a continuous and categorical (1, 2 and 3 to 8) variable. Biochemical recurrence was defined as a prostate specific antigen greater than 0.2 ng/ml, 2 values at 0.2 ng/ml or secondary treatment for an increased prostate specific antigen. The association between number of prior biopsy sessions and biochemical recurrence was analyzed using the Cox proportional hazards model. Kaplan-Meier estimates of freedom from biochemical recurrence were compared among the groups. Results: Of the 2,739 men in the SEARCH database who met the inclusion criteria 2,251 (82%) had only 1 biopsy, 365(13%) had 2 biopsies and 123 (5%) had 3 or more biopsies. More biopsy sessions were associated with higher prostate specific antigen (p

Original languageEnglish (US)
Pages (from-to)2056-2060
Number of pages5
JournalJournal of Urology
Volume187
Issue number6
DOIs
StatePublished - Jun 2012

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Cancer Care Facilities
Prostate
Cohort Studies
Databases
Biopsy
Prostate-Specific Antigen
Recurrence
Prostatectomy
Kaplan-Meier Estimate
Proportional Hazards Models
Prostatic Neoplasms

Keywords

  • biopsy
  • diagnosis
  • prostatectomy
  • prostatic neoplasms
  • recurrence

ASJC Scopus subject areas

  • Urology

Cite this

Kopp, R., Stroup, S. P., Schroeck, F. R., Freedland, S. J., Millard, F., Terris, M. K., ... Kane, C. J. (2012). Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database. Journal of Urology, 187(6), 2056-2060. https://doi.org/10.1016/j.juro.2012.01.083

Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database. / Kopp, Ryan; Stroup, Sean P.; Schroeck, Florian R.; Freedland, Stephen J.; Millard, Frederick; Terris, Martha K.; Aronson, William J.; Presti, Joseph C.; Amling, Christopher; Kane, Christopher J.

In: Journal of Urology, Vol. 187, No. 6, 06.2012, p. 2056-2060.

Research output: Contribution to journalArticle

Kopp, R, Stroup, SP, Schroeck, FR, Freedland, SJ, Millard, F, Terris, MK, Aronson, WJ, Presti, JC, Amling, C & Kane, CJ 2012, 'Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database', Journal of Urology, vol. 187, no. 6, pp. 2056-2060. https://doi.org/10.1016/j.juro.2012.01.083
Kopp R, Stroup SP, Schroeck FR, Freedland SJ, Millard F, Terris MK et al. Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database. Journal of Urology. 2012 Jun;187(6):2056-2060. https://doi.org/10.1016/j.juro.2012.01.083
Kopp, Ryan ; Stroup, Sean P. ; Schroeck, Florian R. ; Freedland, Stephen J. ; Millard, Frederick ; Terris, Martha K. ; Aronson, William J. ; Presti, Joseph C. ; Amling, Christopher ; Kane, Christopher J. / Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database. In: Journal of Urology. 2012 ; Vol. 187, No. 6. pp. 2056-2060.
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