Are physical measures related to patient-centred outcomes in ARDS survivors?

Kitty S. Chan, Lisa Aronson Friedman, Victor D. Dinglas, Catherine L. Hough, Carl Shanholtz, E. Wesley Ely, Peter E. Morris, Pedro A. Mendez-Tellez, James C. Jackson, Ramona O. Hopkins, Dale M. Needham

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Objective To inform selection of physical measures for studies of acute respiratory distress syndrome (ARDS) survivors within 12 months of ARDS. Methods Secondary analysis of data from 6-month survivors participating in a US multicentre prospective study (ARDSNet Long-Term Outcome Study, N=134) or a multisite prospective study in Baltimore, Maryland, USA (Improving Care of Acute Lung Injury Patients, N=99). Physical measures, assessed at 6-month follow-up, were categorised according to the WHO's International Classification of Disability and Health: body functions and structures, activity and participation. Patient-centred outcomes were evaluated at 6 and 12 months: survival, hospitalisation, alive at home status and health-related quality of life. Pearson correlation, linear and logistic regression models were used to quantify associations of physical measures with patient-centred outcomes. Main results No 6-month body functions and structures measure demonstrated consistent association with 6-month or 12-month outcomes in multivariable regression. The 6 min walk test, an activity measure, was associated with 6-month Short-Form 36 (SF-36) physical component scores (PCS, β range: 0.99 to 1.52, p<0.05). Participation measures (Functional Performance Inventory, FPI; Instrumental Activities of Daily Living, IADLs) were associated with SF-36 PCS (β range: FPI, 1.51-1.52; IADL, -1.88 to -1.32; all p<0.05) and Euro-QOL-5D utility score (β range: FPI, 2.00-3.67; IADL, -2.89 to -2.50; all p<0.01) at 6 and 12 months. Conclusions Participation measures better reflect patient's quality of life than measures of body functions and structures within 12 months of ARDS among 6-month survivors, and are recommended for inclusion as a core measure in future studies.

Original languageEnglish (US)
Pages (from-to)884-892
Number of pages9
JournalThorax
Volume72
Issue number10
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

Keywords

  • ARDS

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint

Dive into the research topics of 'Are physical measures related to patient-centred outcomes in ARDS survivors?'. Together they form a unique fingerprint.

Cite this