Are microRNAs true sensors of ageing and cellular senescence?

Justin Williams, Flint Smith, Subodh Kumar, Murali Vijayan, P. Hemachandra Reddy

    Research output: Contribution to journalReview articlepeer-review

    43 Scopus citations

    Abstract

    All living beings are programmed to death due to aging and age-related processes. Aging is a normal process of every living species. While all cells are inevitably progressing towards death, many disease processes accelerate the aging process, leading to senescence. Pathologies such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, cardiovascular disease, cancer, and skin diseases have been associated with deregulated aging. Healthy aging can delay onset of all age-related diseases. Genetics and epigenetics are reported to play large roles in accelerating and/or delaying the onset of age-related diseases. Cellular mechanisms of aging and age-related diseases are not completely understood. However, recent molecular biology discoveries have revealed that microRNAs (miRNAs) are potential sensors of aging and cellular senescence. Due to miRNAs capability to bind to the 3′ untranslated region (UTR) of mRNA of specific genes, miRNAs can prevent the translation of specific genes. The purpose of our article is to highlight recent advancements in miRNAs and their involvement in cellular changes in aging and senescence. Our article discusses the current understanding of cellular senescence, its interplay with miRNAs regulation, and how they both contribute to disease processes.

    Original languageEnglish (US)
    Pages (from-to)350-363
    Number of pages14
    JournalAgeing Research Reviews
    Volume35
    DOIs
    StatePublished - May 1 2017

    Keywords

    • Aging
    • Alzheimer's disease
    • Oxidative-stress
    • Senescence
    • microRNA

    ASJC Scopus subject areas

    • Biotechnology
    • Biochemistry
    • Aging
    • Molecular Biology
    • Neurology

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