Are microRNAs true sensors of ageing and cellular senescence?

Justin Williams, Flint Smith, Subodh Kumar, Murali Vijayan, P (Hemachandra) Reddy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

All living beings are programmed to death due to aging and age-related processes. Aging is a normal process of every living species. While all cells are inevitably progressing towards death, many disease processes accelerate the aging process, leading to senescence. Pathologies such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, cardiovascular disease, cancer, and skin diseases have been associated with deregulated aging. Healthy aging can delay onset of all age-related diseases. Genetics and epigenetics are reported to play large roles in accelerating and/or delaying the onset of age-related diseases. Cellular mechanisms of aging and age-related diseases are not completely understood. However, recent molecular biology discoveries have revealed that microRNAs (miRNAs) are potential sensors of aging and cellular senescence. Due to miRNAs capability to bind to the 3' untranslated region (UTR) of mRNA of specific genes, miRNAs can prevent the translation of specific genes. The purpose of our article is to highlight recent advancements in miRNAs and their involvement in cellular changes in aging and senescence. Our article discusses the current understanding of cellular senescence, its interplay with miRNAs regulation, and how they both contribute to disease processes.

Original languageEnglish (US)
JournalAgeing Research Reviews
DOIs
StateAccepted/In press - Jul 25 2016
Externally publishedYes

Fingerprint

Cell Aging
MicroRNAs
Aging of materials
Sensors
Age of Onset
Huntington Disease
Amyotrophic Lateral Sclerosis
3' Untranslated Regions
Skin Neoplasms
Skin Diseases
Epigenomics
Genes
Multiple Sclerosis
Parkinson Disease
Molecular Biology
Alzheimer Disease
Cardiovascular Diseases
Pathology
Messenger RNA
Molecular biology

Keywords

  • Aging
  • Alzheimer's disease
  • MicroRNA
  • Oxidative-stress
  • Senescence

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Cite this

Williams, J., Smith, F., Kumar, S., Vijayan, M., & Reddy, P. H. (Accepted/In press). Are microRNAs true sensors of ageing and cellular senescence? Ageing Research Reviews. https://doi.org/10.1016/j.arr.2016.11.008

Are microRNAs true sensors of ageing and cellular senescence? / Williams, Justin; Smith, Flint; Kumar, Subodh; Vijayan, Murali; Reddy, P (Hemachandra).

In: Ageing Research Reviews, 25.07.2016.

Research output: Contribution to journalArticle

Williams, Justin ; Smith, Flint ; Kumar, Subodh ; Vijayan, Murali ; Reddy, P (Hemachandra). / Are microRNAs true sensors of ageing and cellular senescence?. In: Ageing Research Reviews. 2016.
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