TY - JOUR
T1 - Architects in neural circuit design
T2 - Glia control neuron numbers and connectivity
AU - Corty, Megan M.
AU - Freeman, Marc R.
PY - 2013/11/11
Y1 - 2013/11/11
N2 - Glia serve many important functions in the mature nervous system. In addition, these diverse cells have emerged as essential participants in nearly all aspects of neural development. Improved techniques to study neurons in the absence of glia, and to visualize and manipulate glia in vivo, have greatly expanded our knowledge of glial biology and neuron-glia interactions during development. Exciting studies in the last decade have begun to identify the cellular and molecular mechanisms by which glia exert control over neuronal circuit formation. Recent findings illustrate the importance of glial cells in shaping the nervous system by controlling the number and connectivity of neurons.
AB - Glia serve many important functions in the mature nervous system. In addition, these diverse cells have emerged as essential participants in nearly all aspects of neural development. Improved techniques to study neurons in the absence of glia, and to visualize and manipulate glia in vivo, have greatly expanded our knowledge of glial biology and neuron-glia interactions during development. Exciting studies in the last decade have begun to identify the cellular and molecular mechanisms by which glia exert control over neuronal circuit formation. Recent findings illustrate the importance of glial cells in shaping the nervous system by controlling the number and connectivity of neurons.
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U2 - 10.1083/jcb.201306099
DO - 10.1083/jcb.201306099
M3 - Review article
C2 - 24217617
AN - SCOPUS:84890231801
SN - 0021-9525
VL - 203
SP - 395
EP - 405
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 3
ER -