Arachidonic Acid Metabolites in Cutaneous Carcinomas: Evidence Suggesting That Elevated Levels of Prostaglandins in Basal Cell Carcinomas Are Associated with an Aggressive Growth Pattern

Evelyn E. Vanderveen, Roy C. Grekin, Neil Swanson, Knud Kragballe

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

There is evidence suggesting a role of eicosanoids in the growth of certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Both BCCs and SCCs contained more prostaglandin E2 and F (PGE2 and PGF) than normal epidermis. In vitro incubation of tumor samples with arachidonic acid also resulted in PGE2 and PGF formation. Basal cell carcinomas exhibiting a histologically aggressive growth pattern contained higher levels of prostaglandins than those with a nonaggressive growth pattern, both in vivo and after in vitro incubation. Lipoxygenase products (12- and 15-hydroxyeicosatetraenoic acid) were present in smaller amounts than cyclo-oxygenase products (PGE2 and PGF) in vivo. Compared with normal epidermis, SCCs and, particularly, BCCs produced smaller amounts of 12-hydroxyeicosatetraenoic acid during in vitro incubation with arachidonic acid. The levels of lipoxygenase products were not related to the tumor growth pattern. These results indicate that excessive prostaglandin levels in BCCs may be associated with an aggressive growth pattern.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalArchives of Dermatology
Volume122
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Basal Cell Carcinoma
Arachidonic Acid
Dinoprost
Prostaglandins
Dinoprostone
Carcinoma
Skin
Hydroxyeicosatetraenoic Acids
Growth
Squamous Cell Carcinoma
Epidermis
Neoplasms
Lipoxygenase
Eicosanoids
Prostaglandin-Endoperoxide Synthases
In Vitro Techniques

ASJC Scopus subject areas

  • Dermatology

Cite this

Arachidonic Acid Metabolites in Cutaneous Carcinomas : Evidence Suggesting That Elevated Levels of Prostaglandins in Basal Cell Carcinomas Are Associated with an Aggressive Growth Pattern. / Vanderveen, Evelyn E.; Grekin, Roy C.; Swanson, Neil; Kragballe, Knud.

In: Archives of Dermatology, Vol. 122, No. 4, 1986, p. 407-412.

Research output: Contribution to journalArticle

@article{03aab8ecad0b4f3091238b33b6977a1c,
title = "Arachidonic Acid Metabolites in Cutaneous Carcinomas: Evidence Suggesting That Elevated Levels of Prostaglandins in Basal Cell Carcinomas Are Associated with an Aggressive Growth Pattern",
abstract = "There is evidence suggesting a role of eicosanoids in the growth of certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Both BCCs and SCCs contained more prostaglandin E2 and F2α (PGE2 and PGF2α) than normal epidermis. In vitro incubation of tumor samples with arachidonic acid also resulted in PGE2 and PGF2α formation. Basal cell carcinomas exhibiting a histologically aggressive growth pattern contained higher levels of prostaglandins than those with a nonaggressive growth pattern, both in vivo and after in vitro incubation. Lipoxygenase products (12- and 15-hydroxyeicosatetraenoic acid) were present in smaller amounts than cyclo-oxygenase products (PGE2 and PGF2α) in vivo. Compared with normal epidermis, SCCs and, particularly, BCCs produced smaller amounts of 12-hydroxyeicosatetraenoic acid during in vitro incubation with arachidonic acid. The levels of lipoxygenase products were not related to the tumor growth pattern. These results indicate that excessive prostaglandin levels in BCCs may be associated with an aggressive growth pattern.",
author = "Vanderveen, {Evelyn E.} and Grekin, {Roy C.} and Neil Swanson and Knud Kragballe",
year = "1986",
doi = "10.1001/archderm.1986.01660160063020",
language = "English (US)",
volume = "122",
pages = "407--412",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Arachidonic Acid Metabolites in Cutaneous Carcinomas

T2 - Evidence Suggesting That Elevated Levels of Prostaglandins in Basal Cell Carcinomas Are Associated with an Aggressive Growth Pattern

AU - Vanderveen, Evelyn E.

AU - Grekin, Roy C.

AU - Swanson, Neil

AU - Kragballe, Knud

PY - 1986

Y1 - 1986

N2 - There is evidence suggesting a role of eicosanoids in the growth of certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Both BCCs and SCCs contained more prostaglandin E2 and F2α (PGE2 and PGF2α) than normal epidermis. In vitro incubation of tumor samples with arachidonic acid also resulted in PGE2 and PGF2α formation. Basal cell carcinomas exhibiting a histologically aggressive growth pattern contained higher levels of prostaglandins than those with a nonaggressive growth pattern, both in vivo and after in vitro incubation. Lipoxygenase products (12- and 15-hydroxyeicosatetraenoic acid) were present in smaller amounts than cyclo-oxygenase products (PGE2 and PGF2α) in vivo. Compared with normal epidermis, SCCs and, particularly, BCCs produced smaller amounts of 12-hydroxyeicosatetraenoic acid during in vitro incubation with arachidonic acid. The levels of lipoxygenase products were not related to the tumor growth pattern. These results indicate that excessive prostaglandin levels in BCCs may be associated with an aggressive growth pattern.

AB - There is evidence suggesting a role of eicosanoids in the growth of certain tumors. In this study, tissue samples were collected from basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Both BCCs and SCCs contained more prostaglandin E2 and F2α (PGE2 and PGF2α) than normal epidermis. In vitro incubation of tumor samples with arachidonic acid also resulted in PGE2 and PGF2α formation. Basal cell carcinomas exhibiting a histologically aggressive growth pattern contained higher levels of prostaglandins than those with a nonaggressive growth pattern, both in vivo and after in vitro incubation. Lipoxygenase products (12- and 15-hydroxyeicosatetraenoic acid) were present in smaller amounts than cyclo-oxygenase products (PGE2 and PGF2α) in vivo. Compared with normal epidermis, SCCs and, particularly, BCCs produced smaller amounts of 12-hydroxyeicosatetraenoic acid during in vitro incubation with arachidonic acid. The levels of lipoxygenase products were not related to the tumor growth pattern. These results indicate that excessive prostaglandin levels in BCCs may be associated with an aggressive growth pattern.

UR - http://www.scopus.com/inward/record.url?scp=0022591178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022591178&partnerID=8YFLogxK

U2 - 10.1001/archderm.1986.01660160063020

DO - 10.1001/archderm.1986.01660160063020

M3 - Article

C2 - 3456741

AN - SCOPUS:0022591178

VL - 122

SP - 407

EP - 412

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 4

ER -