AR, apoE, and cognitive function

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

Original languageEnglish (US)
Pages (from-to)706-715
Number of pages10
JournalHormones and Behavior
Volume53
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Apolipoproteins
Androgen Receptors
Cognition
Androgens
Alzheimer Disease
Testosterone
Estrogens
Clinical Trials
Cognitive Dysfunction

Keywords

  • Androgen receptor
  • apoE4
  • Testosterone
  • tfm

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

AR, apoE, and cognitive function. / Raber, Jacob.

In: Hormones and Behavior, Vol. 53, No. 5, 05.2008, p. 706-715.

Research output: Contribution to journalArticle

Raber, Jacob. / AR, apoE, and cognitive function. In: Hormones and Behavior. 2008 ; Vol. 53, No. 5. pp. 706-715.
@article{d1d1ccf4bac84763a88f6a549f7376ea,
title = "AR, apoE, and cognitive function",
abstract = "Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.",
keywords = "Androgen receptor, apoE4, Testosterone, tfm",
author = "Jacob Raber",
year = "2008",
month = "5",
doi = "10.1016/j.yhbeh.2008.02.012",
language = "English (US)",
volume = "53",
pages = "706--715",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Academic Press Inc.",
number = "5",

}

TY - JOUR

T1 - AR, apoE, and cognitive function

AU - Raber, Jacob

PY - 2008/5

Y1 - 2008/5

N2 - Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

AB - Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

KW - Androgen receptor

KW - apoE4

KW - Testosterone

KW - tfm

UR - http://www.scopus.com/inward/record.url?scp=42649113050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42649113050&partnerID=8YFLogxK

U2 - 10.1016/j.yhbeh.2008.02.012

DO - 10.1016/j.yhbeh.2008.02.012

M3 - Article

C2 - 18395206

AN - SCOPUS:42649113050

VL - 53

SP - 706

EP - 715

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

IS - 5

ER -