AR, apoE, and cognitive function

Jacob Raber

doi:10.1016/j.yhbeh.2008.02.012

AR, apoE, and cognitive function

Jacob Raber

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

Original language	English (US)
Pages (from-to)	706-715
Number of pages	10
Journal	Hormones and Behavior
Volume	53
Issue number	5
DOIs	https://doi.org/10.1016/j.yhbeh.2008.02.012
State	Published - May 2008
Externally published	Yes

Keywords

Androgen receptor
Testosterone
apoE4
tfm

ASJC Scopus subject areas

Endocrinology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1016/j.yhbeh.2008.02.012

Cite this

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title = "AR, apoE, and cognitive function",

abstract = "Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.",

keywords = "Androgen receptor, Testosterone, apoE4, tfm",

author = "Jacob Raber",

note = "Funding Information: This work was supported by EMF AG-NS-0201, NIH Grant R01 AG20904, the Medical Research Foundation of Oregon, a Pilot Project of the Layton Center for Aging and Alzheimer's Disease, PHS Grant 5 M01 RR000334 and Alzheimer's Disease Center NIA Grant P30 AG08017. We would like to thank Clive Wolffendin and his staff at the Oregon Health and Science University General Clinical Research Center for their assistance with the genotyping and testosterone assays for the human study participants.",

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doi = "10.1016/j.yhbeh.2008.02.012",

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PY - 2008/5

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N2 - Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

AB - Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

KW - Androgen receptor

KW - Testosterone

KW - apoE4

KW - tfm

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DO - 10.1016/j.yhbeh.2008.02.012

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SN - 0018-506X

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EP - 715

JO - Hormones and Behavior

JF - Hormones and Behavior

IS - 5

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AR, apoE, and cognitive function

Abstract

Keywords

ASJC Scopus subject areas

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