AR, apoE, and cognitive function

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by ε4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

Original languageEnglish (US)
Pages (from-to)706-715
Number of pages10
JournalHormones and Behavior
Issue number5
StatePublished - May 2008
Externally publishedYes


  • Androgen receptor
  • Testosterone
  • apoE4
  • tfm

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience


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