Apurinic DNA endonuclease activities in repair-deficient human cell lines

Robb E. Moses, Arthur L. Beaudet

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.

Original languageEnglish (US)
Pages (from-to)463-473
Number of pages11
JournalNucleic acids research
Volume5
Issue number2
DOIs
StatePublished - Feb 1978

ASJC Scopus subject areas

  • Genetics

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