Apurinic DNA endonuclease activities in repair-deficient human cell lines

Robb Moses, Arthur L. Beaudet

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.

Original languageEnglish (US)
Pages (from-to)463-473
Number of pages11
JournalNucleic Acids Research
Volume5
Issue number2
DOIs
StatePublished - Feb 1978
Externally publishedYes

Fingerprint

DNA-(Apurinic or Apyrimidinic Site) Lyase
Ataxia Telangiectasia
DNA Repair
Repair
DNA
Defects
Cells
Bloom Syndrome
Fanconi Syndrome
Fanconi Anemia
Dwarfism
Cell Line
Cell Culture
Complementation
Line
Cell
Cell culture
Cell Culture Techniques
Likely
Human

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Apurinic DNA endonuclease activities in repair-deficient human cell lines. / Moses, Robb; Beaudet, Arthur L.

In: Nucleic Acids Research, Vol. 5, No. 2, 02.1978, p. 463-473.

Research output: Contribution to journalArticle

@article{01a9e0d97bac430abbecd95af2946141,
title = "Apurinic DNA endonuclease activities in repair-deficient human cell lines",
abstract = "Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.",
author = "Robb Moses and Beaudet, {Arthur L.}",
year = "1978",
month = "2",
doi = "10.1093/nar/5.2.463",
language = "English (US)",
volume = "5",
pages = "463--473",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Apurinic DNA endonuclease activities in repair-deficient human cell lines

AU - Moses, Robb

AU - Beaudet, Arthur L.

PY - 1978/2

Y1 - 1978/2

N2 - Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.

AB - Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0017804991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017804991&partnerID=8YFLogxK

U2 - 10.1093/nar/5.2.463

DO - 10.1093/nar/5.2.463

M3 - Article

VL - 5

SP - 463

EP - 473

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 2

ER -