Aptamer-crosslinked microbubbles: Smart contrast agents for thrombin-activated ultrasound imaging

Matthew A. Nakatsuka, Robert F. Mattrey, Sadik Esener, Jennifer N. Cha, Andrew P. Goodwin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

Original languageEnglish (US)
Pages (from-to)6010-6016
Number of pages7
JournalAdvanced Materials
Volume24
Issue number45
DOIs
StatePublished - Nov 27 2012
Externally publishedYes

Fingerprint

Thrombin
Contrast Media
Blood
Ultrasonics
Imaging techniques

Keywords

  • aptamer
  • colloid science
  • contrast agents
  • imaging
  • self-assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Aptamer-crosslinked microbubbles : Smart contrast agents for thrombin-activated ultrasound imaging. / Nakatsuka, Matthew A.; Mattrey, Robert F.; Esener, Sadik; Cha, Jennifer N.; Goodwin, Andrew P.

In: Advanced Materials, Vol. 24, No. 45, 27.11.2012, p. 6010-6016.

Research output: Contribution to journalArticle

Nakatsuka, Matthew A. ; Mattrey, Robert F. ; Esener, Sadik ; Cha, Jennifer N. ; Goodwin, Andrew P. / Aptamer-crosslinked microbubbles : Smart contrast agents for thrombin-activated ultrasound imaging. In: Advanced Materials. 2012 ; Vol. 24, No. 45. pp. 6010-6016.
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