Aptamer-crosslinked microbubbles: Smart contrast agents for thrombin-activated ultrasound imaging

Matthew A. Nakatsuka, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha, Andrew P. Goodwin

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

Original languageEnglish (US)
Pages (from-to)6010-6016
Number of pages7
JournalAdvanced Materials
Issue number45
StatePublished - Nov 27 2012
Externally publishedYes


  • aptamer
  • colloid science
  • contrast agents
  • imaging
  • self-assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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