Aptamer-crosslinked microbubbles: Smart contrast agents for thrombin-activated ultrasound imaging

Matthew A. Nakatsuka; Robert F. Mattrey; Sadik C. Esener; Jennifer N. Cha; Andrew P. Goodwin

doi:10.1002/adma.201201484

Aptamer-crosslinked microbubbles: Smart contrast agents for thrombin-activated ultrasound imaging

Matthew A. Nakatsuka, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha, Andrew P. Goodwin

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

Original language	English (US)
Pages (from-to)	6010-6016
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	45
DOIs	https://doi.org/10.1002/adma.201201484
State	Published - Nov 27 2012
Externally published	Yes

Keywords

aptamer
colloid science
contrast agents
imaging
self-assembly

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201201484

Cite this

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abstract = "Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.",

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T2 - Smart contrast agents for thrombin-activated ultrasound imaging

AU - Nakatsuka, Matthew A.

AU - Mattrey, Robert F.

AU - Esener, Sadik C.

AU - Cha, Jennifer N.

AU - Goodwin, Andrew P.

PY - 2012/11/27

Y1 - 2012/11/27

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AB - Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

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KW - colloid science

KW - contrast agents

KW - imaging

KW - self-assembly

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Aptamer-crosslinked microbubbles: Smart contrast agents for thrombin-activated ultrasound imaging

Abstract

Keywords

ASJC Scopus subject areas

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