Appropriate timing and velocity of infusion for the selective staining of parathyroid glands by intravenous methylene blue

Sean Traynor, Jeff R. Adams, Peter Andersen, Edwin Everts, James Cohen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

BACKGROUND: Intraoperative parathyroid gland (PTG) identification by selective staining using methylene blue dye (MB) infusion has been shown effective but the degree of gland staining is inconsistent. METHODS: The effect of timing and rate of MB infusion on gland uptake was investigated in a canine model by infusing MB either rapidly over 3 to 5 minutes (n = 8) or slowly over 30 minutes (n = 4). The pattern of dye uptake in an exposed PTG was determined by standardized serial photography. RESULTS: Earliest uptake occurred between 10 and 20 minutes after infusion, and maximum uptake averaged 21 minutes, earlier than previously described. Rate of infusion did not affect staining. CONCLUSIONS: This rapid uptake of methylene blue by the parathyroid glands suggests that its selective intraoperative use when glands are difficult to locate intraoperatively, rather than a routine preoperative infusion, is possible without significant operative delay. Clinical experience has confirmed this impression.

Original languageEnglish (US)
Pages (from-to)15-17
Number of pages3
JournalAmerican Journal of Surgery
Volume176
Issue number1
DOIs
StatePublished - 1998

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Parathyroid Glands
Methylene Blue
Coloring Agents
Staining and Labeling
Photography
Canidae

ASJC Scopus subject areas

  • Surgery

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Appropriate timing and velocity of infusion for the selective staining of parathyroid glands by intravenous methylene blue. / Traynor, Sean; Adams, Jeff R.; Andersen, Peter; Everts, Edwin; Cohen, James.

In: American Journal of Surgery, Vol. 176, No. 1, 1998, p. 15-17.

Research output: Contribution to journalArticle

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