TY - JOUR
T1 - Approach to ground-glass opacification of the lung
AU - Nowers, Kenneth
AU - Rasband, J. Daniel
AU - Berges, Grant
AU - Gosselin, Marc
PY - 2002/8
Y1 - 2002/8
N2 - There are a number of diseases that present with ground-glass opacification of the lung as a primary manifestation on chest radiography and thin-section computed tomography (CT). These diseases cannot be clearly categorized into the classic classification scheme of airspace and interstitial disease because there are features of both categories seen in the imaging and histologic findings. Ground-glass opacification has, therefore, been categorized as nonspecific by many radiologists. The fact that both the airspaces and interstitial tissues are often involved should have little importance when evaluating radiographs or high-resolution CT (HRCT) images. The role of the radiologist is evolving and is becoming more significant in the clinical evaluation of a patient presenting with so-called interstitial lung disease. In this article, an approach is described that hopefully will lead to an effective and narrow differential diagnosis when a radiologist is confronted with ground-glass opacification. The critical features in evaluating such cases include: (1) the duration of clinical symptoms; (2) the presence or absence of lung fibrosis, especially honeycombing; (3) the patient's history of smoking; and (4) the distribution of the disease. Each of these features is considered in this article in conjunction with the diseases that lead to ground-glass opacification. The recent thinking regarding nonspecific interstitial pneumonia and usual interstitial pneumonia also is discussed.
AB - There are a number of diseases that present with ground-glass opacification of the lung as a primary manifestation on chest radiography and thin-section computed tomography (CT). These diseases cannot be clearly categorized into the classic classification scheme of airspace and interstitial disease because there are features of both categories seen in the imaging and histologic findings. Ground-glass opacification has, therefore, been categorized as nonspecific by many radiologists. The fact that both the airspaces and interstitial tissues are often involved should have little importance when evaluating radiographs or high-resolution CT (HRCT) images. The role of the radiologist is evolving and is becoming more significant in the clinical evaluation of a patient presenting with so-called interstitial lung disease. In this article, an approach is described that hopefully will lead to an effective and narrow differential diagnosis when a radiologist is confronted with ground-glass opacification. The critical features in evaluating such cases include: (1) the duration of clinical symptoms; (2) the presence or absence of lung fibrosis, especially honeycombing; (3) the patient's history of smoking; and (4) the distribution of the disease. Each of these features is considered in this article in conjunction with the diseases that lead to ground-glass opacification. The recent thinking regarding nonspecific interstitial pneumonia and usual interstitial pneumonia also is discussed.
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U2 - 10.1016/S0887-2171(02)90019-3
DO - 10.1016/S0887-2171(02)90019-3
M3 - Article
C2 - 12465687
AN - SCOPUS:0036703895
SN - 0887-2171
VL - 23
SP - 302
EP - 323
JO - Seminars in Ultrasound CT and MRI
JF - Seminars in Ultrasound CT and MRI
IS - 4
ER -