Abstract
Laser energy of 480 nm was applied in 1-μsec pulses varying between 2.2 and 10 mJ to in vitro and in vivo models of cerebral vasospasm. First, the pulsed-dye laser was applied intravascularly via a 320-μm fiber to basilar artery segments from six dogs. The segments were mounted in a vessel-perfusion apparatus and constricted to, on average, 70% of resting diameter by superfusion with dog hemolysate. Immediate increase in basilar artery diameter occurred to a mean of 83% of control. In a second model, the basilar artery was exposed transclivally in the rabbit. In three normal animals, superfusion of the artery with rabbit hemolysate resulted in a reduction of mean vessel diameter to 81% of control. Following extravascular application of the laser, vessels returned to an average of 106% of the resting state. In six rabbits, the basilar artery was constricted by two intracisternal injections of autologous blood, 3 days apart. Two to 4 days after the second injection, the basilar artery was exposed. Extravascular laser treatment from a quartz fiber placed perpendicular to the vessel adventitia resulted in an immediate 53% average increase in caliber to an estimated 107% of control. No reconstriction was observed over a period of up to 5 hours. Morphologically, damage to the arterial wall was slight. This preliminary investigation suggests that the 1-μsec pulsed-dye laser may be of benefit in the treatment of cerebral vasospasm.
Original language | English (US) |
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Pages (from-to) | 271-276 |
Number of pages | 6 |
Journal | Journal of neurosurgery |
Volume | 75 |
Issue number | 2 |
DOIs | |
State | Published - 1991 |
Externally published | Yes |
Keywords
- basilar artery
- dog
- laser
- pulsed-dye laser
- rabbit
- subarachnoid hemorrhage
- vasospasm
ASJC Scopus subject areas
- Surgery
- Clinical Neurology