Application of PCSK9 inhibitors in practice: Challenges and opportunities

Research output: Research - peer-reviewReview article

  • 1 Citations

Abstract

Although the discovery of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and development of therapeutic antagonists represent a major triumph of modern clinical medicine, efforts to implement PCSK9 inhibitors (PCSK9i) in patient care have been sobering. This practical guide examines the barriers and opportunities for the successful application of pharmacological inhibition of PCSK9 in clinical practice through introduction of a new model of care delivery-the PCSK9i clinic.

LanguageEnglish (US)
Pages499-501
Number of pages3
JournalCirculation Research
Volume121
Issue number5
DOIs
StatePublished - Aug 1 2017

Fingerprint

Proprotein Convertase 9
Modern 1601-history
Clinical Medicine
Patient Care
Pharmacology
Therapeutics

Keywords

  • Angina
  • Cholesterol
  • Health
  • Insurance
  • LDL
  • Patient care
  • Secondary prevention
  • Unstable

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Application of PCSK9 inhibitors in practice: Challenges and opportunities",
abstract = "Although the discovery of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and development of therapeutic antagonists represent a major triumph of modern clinical medicine, efforts to implement PCSK9 inhibitors (PCSK9i) in patient care have been sobering. This practical guide examines the barriers and opportunities for the successful application of pharmacological inhibition of PCSK9 in clinical practice through introduction of a new model of care delivery-the PCSK9i clinic.",
keywords = "Angina, Cholesterol, Health, Insurance, LDL, Patient care, Secondary prevention, Unstable",
author = "Kaufman, {Tina M.} and Duell, {P. Barton} and Purnell, {Jonathan Q.} and Cezary Wójcik and Sergio Fazio and Shapiro, {Michael D.}",
year = "2017",
month = "8",
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AU - Fazio,Sergio

AU - Shapiro,Michael D.

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AB - Although the discovery of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and development of therapeutic antagonists represent a major triumph of modern clinical medicine, efforts to implement PCSK9 inhibitors (PCSK9i) in patient care have been sobering. This practical guide examines the barriers and opportunities for the successful application of pharmacological inhibition of PCSK9 in clinical practice through introduction of a new model of care delivery-the PCSK9i clinic.

KW - Angina

KW - Cholesterol

KW - Health

KW - Insurance

KW - LDL

KW - Patient care

KW - Secondary prevention

KW - Unstable

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