Application of microwave chemistry in the etherification of heterocyclic compounds by nucleophilic aromatic substitutions reactions (SNAr)

Nucleophilic substitution on heterocylces such as purine, pyridine, and pyrimidine is usually a challenging task due to complexities of solubility, side reactions, and workup. Therefore, improved synthetic process are warranted specially when there is need to synthesize complex biologically or medicainally important compounds. Our efforts towards this goal have shown microwave irradiation to be an efficient process for SNAr reaction of halogenated amines with alkoxides and allyloxides. An efficient, simple and practical methodology has been developed which provides significant improvement over conventional methods.The utility has been demonstrated through a series of representative amines. Results of these studies will be presented.