Application of microwave chemistry in the etherification of heterocyclic compounds by nucleophilic aromatic substitutions reactions (SNAr)

Jung Ho Jun, Sanjay V. Malhotra

Research output: Contribution to journalConference articlepeer-review

Abstract

Nucleophilic substitution on heterocylces such as purine, pyridine, and pyrimidine is usually a challenging task due to complexities of solubility, side reactions, and workup. Therefore, improved synthetic process are warranted specially when there is need to synthesize complex biologically or medicainally important compounds. Our efforts towards this goal have shown microwave irradiation to be an efficient process for SNAr reaction of halogenated amines with alkoxides and allyloxides. An efficient, simple and practical methodology has been developed which provides significant improvement over conventional methods.The utility has been demonstrated through a series of representative amines. Results of these studies will be presented.

Original languageEnglish (US)
JournalACS National Meeting Book of Abstracts
StatePublished - 2011
Externally publishedYes
Event242nd ACS National Meeting and Exposition - Denver, CO, United States
Duration: Aug 28 2011Sep 1 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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