Appendiceal Neuroendocrine Tumors: Does Colon Resection Improve Outcomes?

Angelena Crown, Vlad V. Simianu, Hagen Kennecke, Alexandra G. Lopez-Aguiar, Mary Dillhoff, Eliza W. Beal, George A. Poultsides, Eleftherios Makris, Kamran Idrees, Paula Marincola Smith, Hari Nathan, Megan Beems, Daniel Abbott, James Barrett, Ryan C. Fields, Jesse Davidson, Shishir K. Maithel, Flavio G. Rocha

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Appendiceal neuroendocrine tumors (A-NETs) are rare neoplasms of the GI tract. They are typically managed according to tumor size; however, the impact of surgical strategy on the short- and long-term outcomes is unknown. Methods: All patients who underwent resection of A-NET at 8 institutions from 2000 to 2016 were analyzed retrospectively. Patient clinicopathologic features and outcomes were stratified according to resection type. Results: Of 61 patients identified with A-NET, mean age of presentation was 44.7 ± 16.0 years and patients were predominantly Caucasian (77%) and female (56%). Mean tumor size was 1.2 ± 1.3 cm with a median of 0.8 cm. Thirty-one patients (51%) underwent appendectomy and 30 (49%) underwent colonic resection. The appendectomy group had more T1 tumors (87% vs 42%, p < 0.01) than the colon resection group. Of patients in the colon resection group, 27% had positive lymph nodes and 3% had M1 disease. R0 resections were achieved in 90% of appendectomy patients and 97% of colon resection patients. Complications occurred with a higher frequency in the colon resection group (30%) compared with those in the appendectomy group (6%, p = 0.02). The colon resection group also had a longer length of stay, higher average blood loss, and longer average OR time. Median RFS and OS were similar between groups. Conclusion: A-NET RFS and OS are equivalent regardless of surgical strategy. Formal colon resection is associated with increased length of stay, OR time, higher blood loss, and more complications. Further study is warranted to identify patients that are likely to benefit from more aggressive surgery.

Original languageEnglish (US)
Pages (from-to)2121-2126
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2020
Externally publishedYes

Keywords

  • Appendectomy
  • Appendiceal neuroendocrine tumor
  • Colectomy

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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