Apparent Protective Effect of Increased Left Ventricular Wall Thickness in an ICD Population

Vivek Dogra, Ronald Oliver, Jodi Lapidus, Seshadri Balaji, Jack Kron, John McAnulty, Sumeet S. Chugh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Expanding indications for the implantable cardioverter defibrillator (ICD) call for further enhancement of patient selection for optimization of use. Because a subgroup of patients who receive ICDs may not receive therapies, we sought to identify clinical predictors of therapy-free survival in ICD patients. Methods: We performed an analysis of a single-center, 13-year ICD implantation experience (1990-2002). The association between therapy-free survival and several clinical variables was evaluated. Results: From a total of 562 patients included in the database, 98 patients (17%) received no shock therapies or antitachycardia pacing (group A). When compared with a randomly selected sample of 131 patients who did receive ICD therapies (group B), there were no significant differences in age, gender, frequency of coronary artery disease, or extent of left ventricular (LV) dysfunction. However, left ventricular hypertrophy (LVH; increased wall thickness by echocardiography) was significantly more common in group A versus group B (30% versus 18%; Pearson's chi-square = 4.69, P = .03). The odds of patients in group A having LVH were 1.98 times higher versus group B (95% confidence interval for odds ratio: 1.06-3.71). Comparisons of calculated mean LV mass between the 2 groups were not significantly different (group A 283 ± 112 gm versus group B 271 ± 108, P = .58). The overall mortality rate was 17% in group A and 22% in group B (P = .29). Conclusions: Increased LV wall thickness was a significant, independent predictor of therapy-free survival in this ICD population. Because LV mass was unchanged, this finding may reflect the importance of LV dilation and wall thinning (ie, eccentric remodeling) as a risk factor for recurrent ventricular arrhythmia in ICD patients.

Original languageEnglish (US)
Pages (from-to)412-415
Number of pages4
JournalJournal of Cardiac Failure
Volume9
Issue number5
DOIs
StatePublished - Oct 2003

Fingerprint

Implantable Defibrillators
Population
Survival
Convulsive Therapy
Left Ventricular Dysfunction
Left Ventricular Hypertrophy
Therapeutics
Group Psychotherapy
Patient Selection
Echocardiography
Cardiac Arrhythmias
Coronary Artery Disease
Dilatation
Odds Ratio
Databases
Confidence Intervals
Mortality

Keywords

  • Arrhythmia
  • Concentric
  • Dilatation
  • Eccentric
  • Implantable cardioverter-defibrillator
  • Left ventricle
  • Recurrence
  • Remodeling
  • Wall

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Apparent Protective Effect of Increased Left Ventricular Wall Thickness in an ICD Population. / Dogra, Vivek; Oliver, Ronald; Lapidus, Jodi; Balaji, Seshadri; Kron, Jack; McAnulty, John; Chugh, Sumeet S.

In: Journal of Cardiac Failure, Vol. 9, No. 5, 10.2003, p. 412-415.

Research output: Contribution to journalArticle

Dogra, Vivek ; Oliver, Ronald ; Lapidus, Jodi ; Balaji, Seshadri ; Kron, Jack ; McAnulty, John ; Chugh, Sumeet S. / Apparent Protective Effect of Increased Left Ventricular Wall Thickness in an ICD Population. In: Journal of Cardiac Failure. 2003 ; Vol. 9, No. 5. pp. 412-415.
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abstract = "Background: Expanding indications for the implantable cardioverter defibrillator (ICD) call for further enhancement of patient selection for optimization of use. Because a subgroup of patients who receive ICDs may not receive therapies, we sought to identify clinical predictors of therapy-free survival in ICD patients. Methods: We performed an analysis of a single-center, 13-year ICD implantation experience (1990-2002). The association between therapy-free survival and several clinical variables was evaluated. Results: From a total of 562 patients included in the database, 98 patients (17{\%}) received no shock therapies or antitachycardia pacing (group A). When compared with a randomly selected sample of 131 patients who did receive ICD therapies (group B), there were no significant differences in age, gender, frequency of coronary artery disease, or extent of left ventricular (LV) dysfunction. However, left ventricular hypertrophy (LVH; increased wall thickness by echocardiography) was significantly more common in group A versus group B (30{\%} versus 18{\%}; Pearson's chi-square = 4.69, P = .03). The odds of patients in group A having LVH were 1.98 times higher versus group B (95{\%} confidence interval for odds ratio: 1.06-3.71). Comparisons of calculated mean LV mass between the 2 groups were not significantly different (group A 283 ± 112 gm versus group B 271 ± 108, P = .58). The overall mortality rate was 17{\%} in group A and 22{\%} in group B (P = .29). Conclusions: Increased LV wall thickness was a significant, independent predictor of therapy-free survival in this ICD population. Because LV mass was unchanged, this finding may reflect the importance of LV dilation and wall thinning (ie, eccentric remodeling) as a risk factor for recurrent ventricular arrhythmia in ICD patients.",
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AU - Dogra, Vivek

AU - Oliver, Ronald

AU - Lapidus, Jodi

AU - Balaji, Seshadri

AU - Kron, Jack

AU - McAnulty, John

AU - Chugh, Sumeet S.

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KW - Dilatation

KW - Eccentric

KW - Implantable cardioverter-defibrillator

KW - Left ventricle

KW - Recurrence

KW - Remodeling

KW - Wall

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