Apoptosis in breast cancer

Haim Werner, Youngman Oh, Charles Roberts

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalAdvances in Cell Aging and Gerontology
Volume6
StatePublished - 2001
Externally publishedYes

Fingerprint

Apoptosis
Breast Neoplasms
Breast
Human Mammary Glands
Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Epithelial Cells
Hormones
Mutation
Growth

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Apoptosis in breast cancer. / Werner, Haim; Oh, Youngman; Roberts, Charles.

In: Advances in Cell Aging and Gerontology, Vol. 6, 2001, p. 1-22.

Research output: Contribution to journalArticle

Werner, Haim ; Oh, Youngman ; Roberts, Charles. / Apoptosis in breast cancer. In: Advances in Cell Aging and Gerontology. 2001 ; Vol. 6. pp. 1-22.
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