Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD

John G. Nutt, Julie H. Carter

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long-duration response (LDR) in seven subjects with fluctuating PD in whom L-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects 'on' during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalNeurology
Volume54
Issue number1
DOIs
StatePublished - Jan 11 2000

Keywords

  • Apomorphine
  • Levodopa
  • Long-duration response
  • Short-duration response

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD'. Together they form a unique fingerprint.

  • Cite this