Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD

John G. Nutt; Julie H. Carter

doi:10.1212/wnl.54.1.247

Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD

John G. Nutt, Julie H. Carter

Neurology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long-duration response (LDR) in seven subjects with fluctuating PD in whom L-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects 'on' during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.

Original language	English (US)
Pages (from-to)	247-250
Number of pages	4
Journal	Neurology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1212/wnl.54.1.247
State	Published - Jan 11 2000

Keywords

Apomorphine
Levodopa
Long-duration response
Short-duration response

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.54.1.247

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KW - Short-duration response

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Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD

Abstract

Keywords

ASJC Scopus subject areas

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