The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long-duration response (LDR) in seven subjects with fluctuating PD in whom L-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects 'on' during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jan 11 2000|
- Long-duration response
- Short-duration response
ASJC Scopus subject areas
- Clinical Neurology