Apolipoprotein E ε4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease

Richard Camicioli, Jeffrey Kaye, Haydeh Payami, Melvyn J. Ball, Geoffrey Murdoch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Apolipoprotein E ε4 (ApoE ε4) is associated with an earlier age at onset of Alzheimer's (AD) and possibly Parkinson's disease, suggesting a general role for ApoE ε4 in neuronal plasticity. Among 31 prospectively assessed subjects with pathologically confirmed AD (without Lewy bodies), ε4+ subjects had a longer duration of disease (by 2.8 years, p = 0.04). Only cell loss in the substantia nigra (p = 0.002) was associated with ε4. Neither neurofibrillary tangles nor plaque counts were associated with ε4. Cell counts of pigmented neurons in single midbrain sections in ε4+ specimens were 72% of those in ε4-substantia nigra (p = 0.04). These findings confirm that cell loss in the substantia nigra is associated with ε4 in AD.

Original languageEnglish (US)
Pages (from-to)437-441
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume10
Issue number6
DOIs
StatePublished - 1999

Fingerprint

Apolipoprotein E4
Substantia Nigra
Alzheimer Disease
Lewy Bodies
Neurofibrillary Tangles
Neuronal Plasticity
Mesencephalon
Age of Onset
Parkinson Disease
Cell Count
Neurons

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Neuronal loss
  • Substantia nigra

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Apolipoprotein E ε4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease. / Camicioli, Richard; Kaye, Jeffrey; Payami, Haydeh; Ball, Melvyn J.; Murdoch, Geoffrey.

In: Dementia and Geriatric Cognitive Disorders, Vol. 10, No. 6, 1999, p. 437-441.

Research output: Contribution to journalArticle

Camicioli, Richard ; Kaye, Jeffrey ; Payami, Haydeh ; Ball, Melvyn J. ; Murdoch, Geoffrey. / Apolipoprotein E ε4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 1999 ; Vol. 10, No. 6. pp. 437-441.
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