Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease

    Research output: Research - peer-reviewReview article

    Abstract

    Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.

    LanguageEnglish (US)
    Article number134
    JournalF1000Research
    Volume6
    DOIs
    StatePublished - 2017

    Fingerprint

    Apolipoproteins B
    Lipoproteins
    Cardiovascular Diseases
    Cholesterol
    Foam Cells
    LDL Lipoproteins
    Cell Communication
    HDL Cholesterol
    Atherosclerosis
    Cardiovascular Agents
    HDL Lipoproteins
    Foams

    Keywords

    • ApoB
    • Apolipoprotein B
    • Arterial degeneration
    • Atherogenic apoB-lipoprotein
    • Atherosclerotic cardiovascular disease
    • Foam cell
    • HDL

    ASJC Scopus subject areas

    • Medicine(all)
    • Immunology and Microbiology(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

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    title = "Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease",
    abstract = "Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.",
    keywords = "ApoB, Apolipoprotein B, Arterial degeneration, Atherogenic apoB-lipoprotein, Atherosclerotic cardiovascular disease, Foam cell, HDL",
    author = "Sergio Fazio and Shapiro, {Michael D.}",
    year = "2017",
    doi = "10.12688/f1000research.9845.1",
    volume = "6",
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    AU - Fazio,Sergio

    AU - Shapiro,Michael D.

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    AB - Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.

    KW - ApoB

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    KW - Arterial degeneration

    KW - Atherogenic apoB-lipoprotein

    KW - Atherosclerotic cardiovascular disease

    KW - Foam cell

    KW - HDL

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