APOE polymorphism in a rural older population-based sample in India

B. K. Thelma, R. C. Juyal, Hiroko Dodge, R. Pandav, V. Chandra, M. Ganguli

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Allele frequencies are most often reported from small convenience samples of unknown demographics and limited generalizability. We determined the distribution of apolipoprotein E genotype (APOE) and allele frequencies for a large, well-defined, representative, rural, population-based sample (n = 4450) aged 55-95 years in Ballabgarh, in the northern Indian state of Haryana. The overall APOE E*2, E*3, and E*4 allele frequencies were 0.039, 0.887, and 0.073, respectively; frequencies are also reported by age, sex, and religious/caste groups. The APOE*4 frequency is among the lowest reported anywhere in the world. APOE allele frequencies did not vary significantly by age or sex in this study. To our knowledge, this is the largest Indian sample ever genotyped for the APOE polymorphism. The representativeness of the sample and its known demographics provide a much-needed normative background for studies of gene-disease associations.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalHuman Biology
Volume73
Issue number1
StatePublished - 2001
Externally publishedYes

Fingerprint

apolipoprotein E
Apolipoproteins E
Rural Population
India
polymorphism
genotype
Gene Frequency
Genotype
genetic polymorphism
gene frequency
allele
sampling
demographic statistics
Demography
Apolipoprotein E4
rural population
caste
gender
Social Class
gene

Keywords

  • Apoe allele frequencies
  • Apoe genetype
  • Indian population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Thelma, B. K., Juyal, R. C., Dodge, H., Pandav, R., Chandra, V., & Ganguli, M. (2001). APOE polymorphism in a rural older population-based sample in India. Human Biology, 73(1), 135-144.

APOE polymorphism in a rural older population-based sample in India. / Thelma, B. K.; Juyal, R. C.; Dodge, Hiroko; Pandav, R.; Chandra, V.; Ganguli, M.

In: Human Biology, Vol. 73, No. 1, 2001, p. 135-144.

Research output: Contribution to journalArticle

Thelma, BK, Juyal, RC, Dodge, H, Pandav, R, Chandra, V & Ganguli, M 2001, 'APOE polymorphism in a rural older population-based sample in India', Human Biology, vol. 73, no. 1, pp. 135-144.
Thelma BK, Juyal RC, Dodge H, Pandav R, Chandra V, Ganguli M. APOE polymorphism in a rural older population-based sample in India. Human Biology. 2001;73(1):135-144.
Thelma, B. K. ; Juyal, R. C. ; Dodge, Hiroko ; Pandav, R. ; Chandra, V. ; Ganguli, M. / APOE polymorphism in a rural older population-based sample in India. In: Human Biology. 2001 ; Vol. 73, No. 1. pp. 135-144.
@article{11328bcc7f2543fca39c8b6d0d27a480,
title = "APOE polymorphism in a rural older population-based sample in India",
abstract = "Allele frequencies are most often reported from small convenience samples of unknown demographics and limited generalizability. We determined the distribution of apolipoprotein E genotype (APOE) and allele frequencies for a large, well-defined, representative, rural, population-based sample (n = 4450) aged 55-95 years in Ballabgarh, in the northern Indian state of Haryana. The overall APOE E*2, E*3, and E*4 allele frequencies were 0.039, 0.887, and 0.073, respectively; frequencies are also reported by age, sex, and religious/caste groups. The APOE*4 frequency is among the lowest reported anywhere in the world. APOE allele frequencies did not vary significantly by age or sex in this study. To our knowledge, this is the largest Indian sample ever genotyped for the APOE polymorphism. The representativeness of the sample and its known demographics provide a much-needed normative background for studies of gene-disease associations.",
keywords = "Apoe allele frequencies, Apoe genetype, Indian population",
author = "Thelma, {B. K.} and Juyal, {R. C.} and Hiroko Dodge and R. Pandav and V. Chandra and M. Ganguli",
year = "2001",
language = "English (US)",
volume = "73",
pages = "135--144",
journal = "Human Biology",
issn = "0018-7143",
publisher = "Wayne State University Press",
number = "1",

}

TY - JOUR

T1 - APOE polymorphism in a rural older population-based sample in India

AU - Thelma, B. K.

AU - Juyal, R. C.

AU - Dodge, Hiroko

AU - Pandav, R.

AU - Chandra, V.

AU - Ganguli, M.

PY - 2001

Y1 - 2001

N2 - Allele frequencies are most often reported from small convenience samples of unknown demographics and limited generalizability. We determined the distribution of apolipoprotein E genotype (APOE) and allele frequencies for a large, well-defined, representative, rural, population-based sample (n = 4450) aged 55-95 years in Ballabgarh, in the northern Indian state of Haryana. The overall APOE E*2, E*3, and E*4 allele frequencies were 0.039, 0.887, and 0.073, respectively; frequencies are also reported by age, sex, and religious/caste groups. The APOE*4 frequency is among the lowest reported anywhere in the world. APOE allele frequencies did not vary significantly by age or sex in this study. To our knowledge, this is the largest Indian sample ever genotyped for the APOE polymorphism. The representativeness of the sample and its known demographics provide a much-needed normative background for studies of gene-disease associations.

AB - Allele frequencies are most often reported from small convenience samples of unknown demographics and limited generalizability. We determined the distribution of apolipoprotein E genotype (APOE) and allele frequencies for a large, well-defined, representative, rural, population-based sample (n = 4450) aged 55-95 years in Ballabgarh, in the northern Indian state of Haryana. The overall APOE E*2, E*3, and E*4 allele frequencies were 0.039, 0.887, and 0.073, respectively; frequencies are also reported by age, sex, and religious/caste groups. The APOE*4 frequency is among the lowest reported anywhere in the world. APOE allele frequencies did not vary significantly by age or sex in this study. To our knowledge, this is the largest Indian sample ever genotyped for the APOE polymorphism. The representativeness of the sample and its known demographics provide a much-needed normative background for studies of gene-disease associations.

KW - Apoe allele frequencies

KW - Apoe genetype

KW - Indian population

UR - http://www.scopus.com/inward/record.url?scp=0035060674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035060674&partnerID=8YFLogxK

M3 - Article

C2 - 11332642

AN - SCOPUS:0035060674

VL - 73

SP - 135

EP - 144

JO - Human Biology

JF - Human Biology

SN - 0018-7143

IS - 1

ER -