apoE isoforms and measures of anxiety in probable AD patients and Apoe -/- mice

Jennifer Robertson, Justine Curley, Jeffrey Kaye, Joseph Quinn, Timothy Pfankuch, Jacob Raber

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe -/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe -/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with ε4/ε4 showed higher anxiety scores than those with ε3/ε3. We conclude that human apoE isoforms have differential effects on measures of anxiety.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalNeurobiology of Aging
Volume26
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Apolipoproteins E
Protein Isoforms
Anxiety
Apolipoprotein E3
Apolipoprotein E4
Microtubule-Associated Proteins
Dendrites
Brain

Keywords

  • Alzheimer's disease
  • Amygdala
  • Anxiety
  • apoE
  • MAP-2

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

apoE isoforms and measures of anxiety in probable AD patients and Apoe -/- mice. / Robertson, Jennifer; Curley, Justine; Kaye, Jeffrey; Quinn, Joseph; Pfankuch, Timothy; Raber, Jacob.

In: Neurobiology of Aging, Vol. 26, No. 5, 05.2005, p. 637-643.

Research output: Contribution to journalArticle

Robertson, Jennifer ; Curley, Justine ; Kaye, Jeffrey ; Quinn, Joseph ; Pfankuch, Timothy ; Raber, Jacob. / apoE isoforms and measures of anxiety in probable AD patients and Apoe -/- mice. In: Neurobiology of Aging. 2005 ; Vol. 26, No. 5. pp. 637-643.
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