Abstract
Objective: To describe the current approach to diagnosis and treatment of aplastic anemia. Methods: Review of the literature. Results: Aplastic anemia can be acquired or associated with an inherited marrow failure syndrome (IMFS), and the treatment and prognosis vary dramatically between these 2 etiologies. Patients may present along a spectrum, ranging from being asymptomatic with incidental findings on peripheral blood testing to life-threatening neutropenic infections or bleeding. Workup and diagnosis involves investigating IMFSs and ruling out malignant or infectious etiologies for pancytopenia. Conclusion: Treatment outcomes are excellent with modern supportive care and the current approach to allogeneic transplantation, and therefore referral to a bone marrow transplant program to evaluate for early transplantation is the new standard of care for aplastic anemia.
Original language | English (US) |
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Pages (from-to) | 229-240 |
Number of pages | 12 |
Journal | Journal of Clinical Outcomes Management |
Volume | 26 |
Issue number | 5 |
State | Published - 2019 |
Keywords
- Fanconi anemia
- Immunosuppression
- Inherited marrow failure syndrome
- Stem cell
- Transplant
ASJC Scopus subject areas
- Health Policy