Aplastic anemia: Diagnosis and treatment

Gabrielle Meyers, Curtis Lachowiez

    Research output: Contribution to journalReview article

    Abstract

    Objective: To describe the current approach to diagnosis and treatment of aplastic anemia. Methods: Review of the literature. Results: Aplastic anemia can be acquired or associated with an inherited marrow failure syndrome (IMFS), and the treatment and prognosis vary dramatically between these 2 etiologies. Patients may present along a spectrum, ranging from being asymptomatic with incidental findings on peripheral blood testing to life-threatening neutropenic infections or bleeding. Workup and diagnosis involves investigating IMFSs and ruling out malignant or infectious etiologies for pancytopenia. Conclusion: Treatment outcomes are excellent with modern supportive care and the current approach to allogeneic transplantation, and therefore referral to a bone marrow transplant program to evaluate for early transplantation is the new standard of care for aplastic anemia.

    Original languageEnglish (US)
    Pages (from-to)229-240
    Number of pages12
    JournalJournal of Clinical Outcomes Management
    Volume26
    Issue number5
    StatePublished - Jan 1 2019

    Keywords

    • Fanconi anemia
    • Immunosuppression
    • Inherited marrow failure syndrome
    • Stem cell
    • Transplant

    ASJC Scopus subject areas

    • Health Policy

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