Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons

Vincent Seutin; Steven W. Johnson; R. Alan North

doi:10.1016/0006-8993(93)90675-D

Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons

Vincent Seutin, Steven W. Johnson, R. Alan North

Neurology

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-d-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.

Original language	English (US)
Pages (from-to)	341-344
Number of pages	4
Journal	Brain research
Volume	630
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)90675-D
State	Published - Dec 10 1993

Keywords

Apamin
Burst-firing
Ventral tegmental area

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90675-D

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title = "Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons",

abstract = "Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-d-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.",

keywords = "Apamin, Burst-firing, Ventral tegmental area",

author = "Vincent Seutin and Johnson, {Steven W.} and North, {R. Alan}",

note = "Funding Information: This work was supported by grants from the NIH and the North Atlantic Treaty Organ±sat±on (V.S.), the Fondation I_~on Fr~d~ricq of the University of Liege (V.S.), the National Parkinson Foundation (S.W.J.) and by Grants DA03161, MH40416 (R.A.N.) and NS01423 (S.W.J.) from the U.S. Department of Health and Human Services.",

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T1 - Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons

AU - Seutin, Vincent

AU - Johnson, Steven W.

AU - North, R. Alan

N1 - Funding Information: This work was supported by grants from the NIH and the North Atlantic Treaty Organ±sat±on (V.S.), the Fondation I_~on Fr~d~ricq of the University of Liege (V.S.), the National Parkinson Foundation (S.W.J.) and by Grants DA03161, MH40416 (R.A.N.) and NS01423 (S.W.J.) from the U.S. Department of Health and Human Services.

PY - 1993/12/10

Y1 - 1993/12/10

N2 - Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-d-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.

AB - Intracellular recordings made in vitro from rat midbrain dopamine neurons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of action potentials in N-methyl-d-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium-activated potassium current, it increased the depolarizing action of NMDA.

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KW - Burst-firing

KW - Ventral tegmental area

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Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons

Abstract

Keywords

ASJC Scopus subject areas

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