@article{00e10c4f074a4711851df73d8838b381,
title = "Apalutamide and Overall Survival in Prostate Cancer",
abstract = "Apalutamide increased overall survival and delayed time to initiation of cytotoxic chemotherapy versus placebo in patients with nonmetastatic castration-resistant prostate cancer. Prior analyses had demonstrated clinically impactful improvement in metastasis-free survival, time to symptomatic progression, and second progression-free survival with apalutamide.",
keywords = "Apalutamide, Nonmetastatic castration-resistant prostate cancer, Overall survival, Subsequent therapy, Time to cytotoxic chemotherapy",
author = "Smith, {Matthew R.} and Fred Saad and Simon Chowdhury and St{\'e}phane Oudard and Hadaschik, {Boris A.} and Graff, {Julie N.} and David Olmos and Mainwaring, {Paul N.} and Lee, {Ji Youl} and Hiroji Uemura and {De Porre}, Peter and Smith, {Andressa A.} and Brookman-May, {Sabine D.} and Susan Li and Ke Zhang and Brendan Rooney and Angela Lopez-Gitlitz and Small, {Eric J.}",
note = "Funding Information: Funding/Support and role of the sponsor : The trial was designed by two of the academic authors and representatives of the Aragon Pharmaceuticals. The sponsor commissioned an independent data and safety monitoring committee to review safety data the results of the primary efficacy analysis before unblinding. Data were transcribed, by trial personnel at each clinical site, from source documents into electronic case-report forms prepared by the sponsor. All the authors had access to the data, drafted the manuscript with input from the sponsor (Janssen), reviewed and approved the manuscript before submission, and made the decision to submit the manuscript for publication. The SPARTAN study was funded by Janssen Research & Development . Janssen Global Services, LLC provided funding for editorial assistance. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
doi = "10.1016/j.eururo.2020.08.011",
language = "English (US)",
volume = "79",
pages = "150--158",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "1",
}