Aortic endograft and epithelioid sarcoma: A random association or causality?

Nitin Tiwari, Sheila Krishna, Alex Ortega Loayza

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Angiosarcoma is an uncommon, malignant neoplasm often found in skin and soft tissue. Epithelioid angiosarcoma (EA) is a rarer, more aggressive form of angiosarcoma most common in men in their seventh decade. Dacron®, a polymer comprised of polyethylene terephthalate used in endografts for abdominal aortic aneurysm repairs, has been a suspected carcinogen associated with EA. Currently, three case reports exist in the literature purporting Dacron®-associated epithelioid angiosarcoma. Herein we report a case of Dacron®-associated EA. CASE: A 64-year-old male with a recent history of a repaired type 2 endoleak and Dacron® endograft for his AAA presented with a painful skin eruption, fever, and weight loss. On exam, erythematous and violaceous papules and nodules were present on the patient's lower back. Biopsy revealed atypical, epithelioid cells forming vascular channels in a sheet-like and infiltrative pattern. These results and subsequent immunostaining were consistent with the diagnosis of EA. A bone marrow biopsy confirmed metastatic angiosarcoma. Conclusion: This case further highlights Dacron® as a rare, but, potential carcinogen associated with EA.

Original languageEnglish (US)
Pages (from-to)897-899
Number of pages3
JournalJournal of Drugs in Dermatology
Volume15
Issue number7
StatePublished - Jul 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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