AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction

Stefano Bonora, Yifan Jian, Edward N. Pugh, Marinko V. Sarunic, Robert J. Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
PublisherSPIE
ISBN (Print)9780819498472
DOIs
StatePublished - Jan 1 2013
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII - San Francisco, CA, United States
Duration: Feb 3 2014Feb 5 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8934
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
CountryUnited States
CitySan Francisco, CA
Period2/3/142/5/14

Fingerprint

Optical tomography
Optical Coherence Tomography
Wavefronts
Aberrations
Lenses
mice
aberration
Adaptive optics
retina
tomography
lenses
adaptive optics
Imaging techniques
Retina
Astigmatism
astigmatism
coma
Coma
Quality Improvement
Image quality

Keywords

  • Aberration compensation
  • Adaptive optics
  • Imaging system
  • Optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Bonora, S., Jian, Y., Pugh, E. N., Sarunic, M. V., & Zawadzki, R. J. (2013). AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII [89340Q] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8934). SPIE. https://doi.org/10.1117/12.2042018

AO-OCT for in vivo mouse retinal imaging : Application of adaptive lens in wavefornt sensorless aberration correction. / Bonora, Stefano; Jian, Yifan; Pugh, Edward N.; Sarunic, Marinko V.; Zawadzki, Robert J.

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII. SPIE, 2013. 89340Q (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8934).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bonora, S, Jian, Y, Pugh, EN, Sarunic, MV & Zawadzki, RJ 2013, AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII., 89340Q, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8934, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, San Francisco, CA, United States, 2/3/14. https://doi.org/10.1117/12.2042018
Bonora S, Jian Y, Pugh EN, Sarunic MV, Zawadzki RJ. AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII. SPIE. 2013. 89340Q. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2042018
Bonora, Stefano ; Jian, Yifan ; Pugh, Edward N. ; Sarunic, Marinko V. ; Zawadzki, Robert J. / AO-OCT for in vivo mouse retinal imaging : Application of adaptive lens in wavefornt sensorless aberration correction. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII. SPIE, 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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