Antiviral drug resistance in human cytomegalovirus

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Drug-resistant cytomegalovirus (CMV) should be considered when viral shedding persists after several weeks of therapy. The problem is most likely to arise in the setting of a severely immunosuppressed host with continuing or relapsing disease. Not all treatment failure can be attributed to drug resistance. The testing of CMV isolates for drug resistance in cell culture is time-consuming and labor-intensive, but recent advances in understanding of the genetics of resistance have resulted in rapid genotypic assays for specific mutations in the viral UL97 phosphotransferase or UL54 DNA polymerase genes that can predict resistance and cross-resistance to specific drugs. This information may help in the selection of alternative therapy.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalTransplant Infectious Disease
Volume1
Issue number2
StatePublished - Jun 1999

Fingerprint

Viral Drug Resistance
Cytomegalovirus
Drug Resistance
Virus Shedding
Immunocompromised Host
DNA-Directed DNA Polymerase
Complementary Therapies
Treatment Failure
Pharmaceutical Preparations
Phosphotransferases
Cell Culture Techniques
Mutation
Genes
Therapeutics

Keywords

  • Antiviral
  • Cytomegalovirus
  • Drug resistance

ASJC Scopus subject areas

  • Transplantation
  • Microbiology (medical)
  • Immunology

Cite this

Antiviral drug resistance in human cytomegalovirus. / Chou, Sunwen.

In: Transplant Infectious Disease, Vol. 1, No. 2, 06.1999, p. 105-114.

Research output: Contribution to journalArticle

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