Antiviral completion rates and sustained viral response in hepatitis C patients with and without preexisting major depressive disorder

Peter Hauser, Benjamin J. Morasco, Alex Linke, Dannell Bjornson, Samantha Ruimy, Annette Matthews, Aly Rifai, David W. Indest, Jennifer M. Loftis

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: Despite evidence suggesting that the majority of patients with hepatitis C virus (HCV) have psychiatric and substance use disorders, patients with these comorbidities have historically been excluded from antiviral therapy for HCV. Objective: The authors compared antiviral completion and sustained virologic response (SVR) rates between hepatitis C (HCV) patients with versus those without preexisting major depressive disorder (MDD). Method: The authors performed a chart review of HCV patients (30 with MDD and 25 control subjects) who attended an optional HCV education class and signed informed consent allowing collection of clinical data. Results: The MDD group had completion and SVR rates similar to those of control subjects. Neuropsychiatric side effects and reasons for discontinuation of treatment were not different between groups. Conclusion: Patients with MDD can be safely and effectively treated with antiviral therapy.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
JournalPsychosomatics
Volume50
Issue number5
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

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