Abstract
CD8+ T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8+ T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8+ T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8+ T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8+ T cell responses can exist in a chronic human viral infection, and may contribute to immune control.
Original language | English (US) |
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Pages (from-to) | 917-930 |
Number of pages | 14 |
Journal | Immunity |
Volume | 45 |
Issue number | 4 |
DOIs | |
State | Published - Oct 18 2016 |
Keywords
- CD8 T cells
- HIV
- HLA
- MHC class II
- TCR
- vaccines
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases