Antisera to an axolemma-enriched fraction inhibit neurite outgrowth and destroy axons in vitro

Dennis Bourdette, Fredrick J. Seil, John W. Bigbee, George H. DeVries, Margaret M. Garwood, Harish C. Agrawal

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Antisera prepared to an axolemma-enriched fraction derived from rat brain inhibited neurite outgrowth and destroyed mature axons in spinal cord-dorsal root ganglia cultures. Similar antibody-mediated anti-axon effects may be important in some diseases of the human nervous system.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalBrain Research
Volume366
Issue number1-2
DOIs
Publication statusPublished - Feb 26 1986

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Keywords

  • anti-axolemma antibody
  • anti-axon antibody
  • axolemma
  • neural tissue culture

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Bourdette, D., Seil, F. J., Bigbee, J. W., DeVries, G. H., Garwood, M. M., & Agrawal, H. C. (1986). Antisera to an axolemma-enriched fraction inhibit neurite outgrowth and destroy axons in vitro. Brain Research, 366(1-2), 333-337. https://doi.org/10.1016/0006-8993(86)91313-2