Antipsychotic drug exposure in a health maintenance organization

Richard E. Johnson, Bentson McFarland

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In this study, exposure to antipsychotic drugs among ambulatory health maintenance organization (HMO) members is described. The diagnoses and mental health utilization associated with their use are explored, and concomitant drug use is investigated. The antipsychotic prescriptions were retrieved from an automated outpatient pharmacy data base for 2 years. Diagnoses for a two-percent sample of users were retrieved from an automated outpatient utilization data base. During the 2 years, 1,959 HMO members received 10,361 prescriptions for antipsychotics. Fifty-eight percent were female, and the mean age of users was 62 years of age. Haloperidol and thioridazine were the most frequently received drugs. Mean annual exposure to antipsychotics was 0.43% of the HMO population; estimated duration of exposure was 170 days; and estimated mean daily dose was 176 mg of chlorpromazine equivalents. Duration of exposure and mean daily dose were directly related. Both were also related to sex and age of users. Antipsychotic users were more likely to be exposed to various therapeutic classes of drugs indicative of chronic diseases. Antipsychotic exposure among ambulatory HMO members appeared to be conservative in terms of prevalence and similar to national experience in terms of daily dose. Estimated days of exposure appeared to place some users at increased risk of developing tardive dyskinesia, and the frequent and varied concomitant drug exposures can complicate treatment.

Original languageEnglish (US)
Pages (from-to)432-444
Number of pages13
JournalMedical Care
Volume31
Issue number5
StatePublished - 1993

Fingerprint

Health Maintenance Organizations
Antipsychotic Agents
drug
organization
health
medication
Pharmaceutical Preparations
utilization
Prescriptions
Outpatients
Databases
Thioridazine
Chlorpromazine
Haloperidol
drug use
mental health
Mental Health
Disease
Chronic Disease
Therapeutics

Keywords

  • Antipsychotic
  • Drug utilization
  • Health maintenance organization
  • Outpatient

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Nursing(all)
  • Health(social science)
  • Health Professions(all)

Cite this

Johnson, R. E., & McFarland, B. (1993). Antipsychotic drug exposure in a health maintenance organization. Medical Care, 31(5), 432-444.

Antipsychotic drug exposure in a health maintenance organization. / Johnson, Richard E.; McFarland, Bentson.

In: Medical Care, Vol. 31, No. 5, 1993, p. 432-444.

Research output: Contribution to journalArticle

Johnson, RE & McFarland, B 1993, 'Antipsychotic drug exposure in a health maintenance organization', Medical Care, vol. 31, no. 5, pp. 432-444.
Johnson, Richard E. ; McFarland, Bentson. / Antipsychotic drug exposure in a health maintenance organization. In: Medical Care. 1993 ; Vol. 31, No. 5. pp. 432-444.
@article{8705ed1ca42a4f0eb7943b3a51376fde,
title = "Antipsychotic drug exposure in a health maintenance organization",
abstract = "In this study, exposure to antipsychotic drugs among ambulatory health maintenance organization (HMO) members is described. The diagnoses and mental health utilization associated with their use are explored, and concomitant drug use is investigated. The antipsychotic prescriptions were retrieved from an automated outpatient pharmacy data base for 2 years. Diagnoses for a two-percent sample of users were retrieved from an automated outpatient utilization data base. During the 2 years, 1,959 HMO members received 10,361 prescriptions for antipsychotics. Fifty-eight percent were female, and the mean age of users was 62 years of age. Haloperidol and thioridazine were the most frequently received drugs. Mean annual exposure to antipsychotics was 0.43{\%} of the HMO population; estimated duration of exposure was 170 days; and estimated mean daily dose was 176 mg of chlorpromazine equivalents. Duration of exposure and mean daily dose were directly related. Both were also related to sex and age of users. Antipsychotic users were more likely to be exposed to various therapeutic classes of drugs indicative of chronic diseases. Antipsychotic exposure among ambulatory HMO members appeared to be conservative in terms of prevalence and similar to national experience in terms of daily dose. Estimated days of exposure appeared to place some users at increased risk of developing tardive dyskinesia, and the frequent and varied concomitant drug exposures can complicate treatment.",
keywords = "Antipsychotic, Drug utilization, Health maintenance organization, Outpatient",
author = "Johnson, {Richard E.} and Bentson McFarland",
year = "1993",
language = "English (US)",
volume = "31",
pages = "432--444",
journal = "Medical Care",
issn = "0025-7079",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Antipsychotic drug exposure in a health maintenance organization

AU - Johnson, Richard E.

AU - McFarland, Bentson

PY - 1993

Y1 - 1993

N2 - In this study, exposure to antipsychotic drugs among ambulatory health maintenance organization (HMO) members is described. The diagnoses and mental health utilization associated with their use are explored, and concomitant drug use is investigated. The antipsychotic prescriptions were retrieved from an automated outpatient pharmacy data base for 2 years. Diagnoses for a two-percent sample of users were retrieved from an automated outpatient utilization data base. During the 2 years, 1,959 HMO members received 10,361 prescriptions for antipsychotics. Fifty-eight percent were female, and the mean age of users was 62 years of age. Haloperidol and thioridazine were the most frequently received drugs. Mean annual exposure to antipsychotics was 0.43% of the HMO population; estimated duration of exposure was 170 days; and estimated mean daily dose was 176 mg of chlorpromazine equivalents. Duration of exposure and mean daily dose were directly related. Both were also related to sex and age of users. Antipsychotic users were more likely to be exposed to various therapeutic classes of drugs indicative of chronic diseases. Antipsychotic exposure among ambulatory HMO members appeared to be conservative in terms of prevalence and similar to national experience in terms of daily dose. Estimated days of exposure appeared to place some users at increased risk of developing tardive dyskinesia, and the frequent and varied concomitant drug exposures can complicate treatment.

AB - In this study, exposure to antipsychotic drugs among ambulatory health maintenance organization (HMO) members is described. The diagnoses and mental health utilization associated with their use are explored, and concomitant drug use is investigated. The antipsychotic prescriptions were retrieved from an automated outpatient pharmacy data base for 2 years. Diagnoses for a two-percent sample of users were retrieved from an automated outpatient utilization data base. During the 2 years, 1,959 HMO members received 10,361 prescriptions for antipsychotics. Fifty-eight percent were female, and the mean age of users was 62 years of age. Haloperidol and thioridazine were the most frequently received drugs. Mean annual exposure to antipsychotics was 0.43% of the HMO population; estimated duration of exposure was 170 days; and estimated mean daily dose was 176 mg of chlorpromazine equivalents. Duration of exposure and mean daily dose were directly related. Both were also related to sex and age of users. Antipsychotic users were more likely to be exposed to various therapeutic classes of drugs indicative of chronic diseases. Antipsychotic exposure among ambulatory HMO members appeared to be conservative in terms of prevalence and similar to national experience in terms of daily dose. Estimated days of exposure appeared to place some users at increased risk of developing tardive dyskinesia, and the frequent and varied concomitant drug exposures can complicate treatment.

KW - Antipsychotic

KW - Drug utilization

KW - Health maintenance organization

KW - Outpatient

UR - http://www.scopus.com/inward/record.url?scp=0027601402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027601402&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 432

EP - 444

JO - Medical Care

JF - Medical Care

SN - 0025-7079

IS - 5

ER -