Antiplatelet and Anticoagulant Therapy after Coronary Bypass

Itzhak D. Goldberg, Michael B. Stemerman, Laurence Klotz, Steven J. Phillips, Chamnahn Kongtahworn, Robert H. Zeff, Shirley E. Beshany, Hendrick B. Barner, George Pantely, Scott H. Goodnight, Shahbudin H. Rahimtoola

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    Abstract

    To the Editor: The paper by Pantely et al. demonstrated that when antiplatelet therapy was instituted three days after coronary-artery bypass, there was no improvement in graft patency.1 Platelet adhesion and release of platelet products into the vessel wall are presumably related to vascular myointimal proliferation and release of a platelet-derived mitogen that stimulates smooth-muscle cells to proliferate.2 Experimental studies have confirmed this hypothesis by showing that myointimal proliferation after endothelial injury can be prevented by rendering animals thrombocytopenic before the injury.3 However, platelet granules are released almost immediately after endothelial injury, as shown in several studies of platelet turnover. . No extract is available for articles shorter than 400 words.

    Original languageEnglish (US)
    Pages (from-to)865-866
    Number of pages2
    JournalNew England Journal of Medicine
    Volume302
    Issue number15
    DOIs
    Publication statusPublished - Apr 10 1980

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    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Goldberg, I. D., Stemerman, M. B., Klotz, L., Phillips, S. J., Kongtahworn, C., Zeff, R. H., ... Rahimtoola, S. H. (1980). Antiplatelet and Anticoagulant Therapy after Coronary Bypass. New England Journal of Medicine, 302(15), 865-866. https://doi.org/10.1056/NEJM198004103021516