Antiphospholipid antibody syndrome

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    This chapter reviews antiphospholipid antibody syndrome–its features, diagnosis, and therapy. Manifestations of APLA including stroke, venous thrombosis, thrombocytopenia, and pregnancy complications are discussed. APLA are antibodies directed against certain phospholipids. They are found in a variety of clinical situations. APLA are important to detect because in certain patients they are associated with a syndrome which includes a hypercoagulable state, thrombocytopenia, fetal loss, dementia, strokes, optic changes, Addisonõs disease, and skin rashes. The underlying mechanism leading to the clinical syndrome associated with APLA is still unknown. Perhaps the antibodies inhibit the function of proteins C or S, damage the endothelium, activate platelets, or inhibit prostacyclin. Despite several decades of research, the etiology of the thrombotic tendency associated with APLA remains unknown.

    Original languageEnglish (US)
    Title of host publicationHemostasis and Thrombosis, Third Edition
    PublisherSpringer International Publishing
    Pages95-99
    Number of pages5
    ISBN (Print)9783319093123, 9783319093116
    DOIs
    StatePublished - Jan 1 2015

    Fingerprint

    Antiphospholipid Syndrome
    Thrombocytopenia
    Stroke
    Addison Disease
    Antiphospholipid Antibodies
    Pregnancy Complications
    Antibodies
    Protein S
    Epoprostenol
    Protein C
    Exanthema
    Venous Thrombosis
    Endothelium
    Dementia
    Phospholipids
    Blood Platelets
    Research
    Therapeutics

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Deloughery, T. (2015). Antiphospholipid antibody syndrome. In Hemostasis and Thrombosis, Third Edition (pp. 95-99). Springer International Publishing. https://doi.org/10.1007/978-3-319-09312-3_19

    Antiphospholipid antibody syndrome. / Deloughery, Thomas.

    Hemostasis and Thrombosis, Third Edition. Springer International Publishing, 2015. p. 95-99.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Deloughery, T 2015, Antiphospholipid antibody syndrome. in Hemostasis and Thrombosis, Third Edition. Springer International Publishing, pp. 95-99. https://doi.org/10.1007/978-3-319-09312-3_19
    Deloughery T. Antiphospholipid antibody syndrome. In Hemostasis and Thrombosis, Third Edition. Springer International Publishing. 2015. p. 95-99 https://doi.org/10.1007/978-3-319-09312-3_19
    Deloughery, Thomas. / Antiphospholipid antibody syndrome. Hemostasis and Thrombosis, Third Edition. Springer International Publishing, 2015. pp. 95-99
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