Antiphospholipid antibodies and retinal vascular disease

James P. Dunn, S. W. Noorily, M. Petri, D. Finkelstein, James (Jim) Rosenbaum, D. A. Jabs

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background. Antiphospholipid antibody retinopathy is a rare and poorly defined clinical entity in which the proper diagnosis has important ocular and systemic implications. The clinical course of five patients with antiphospholipid antibody retinopathy is described and the role of such antibodies in idiopathic retinal venous occlusive disease is investigated. Methods. Five case reports are presented highlighting the presentation, course, therapy, associations and outcomes of patients with antiphospholipid antibody retinopathy. In addition, twenty additional patients presenting with idiopathic retinal venous occlusive disease were tested for the presence of antiphospholipid antibodies. Results. All five patients with antiphospholipid antibody retinopathy had diffuse retinal vascular occlusion. All five patients presented with associated rheumatologic disease, including three with lupus or lupus-like disease. Antibodies to antiphospholipid were not detected in any of the twenty patients with idiopathic retinal venous occlusive disease. Prompt pan-retinal photocoagulation together with varying regimens of corticosteroids, immunosuppressives, or warfarin was partially successful in stabilizing the ocular and systemic disease. Conclusion. The diagnosis of antiphospholipid antibody retinopathy should be suspected in patients with diffuse retinal vaso-occlusion, particularly when characterized by involvement of both arteries and veins, neovascularization at presentation, and symptoms of systemic rheumatologic disease. Antiphospholipid antibodies do not appear to play an important role in idiopathic retinal vein occlusions.

Original languageEnglish (US)
Pages (from-to)313-322
Number of pages10
JournalLupus
Volume5
Issue number4
StatePublished - 1996

Fingerprint

Retinal Diseases
Retinal Vessels
Antiphospholipid Antibodies
Vascular Diseases
Retinal Vein Occlusion
Eye Diseases
Light Coagulation
Warfarin
Immunosuppressive Agents
Veins
Adrenal Cortex Hormones
Arteries
Antibodies

Keywords

  • Antiphospholipid antibody
  • Lupus anticoagulant
  • Retinal neovascularization
  • Retinal vein occlusion
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Dunn, J. P., Noorily, S. W., Petri, M., Finkelstein, D., Rosenbaum, J. J., & Jabs, D. A. (1996). Antiphospholipid antibodies and retinal vascular disease. Lupus, 5(4), 313-322.

Antiphospholipid antibodies and retinal vascular disease. / Dunn, James P.; Noorily, S. W.; Petri, M.; Finkelstein, D.; Rosenbaum, James (Jim); Jabs, D. A.

In: Lupus, Vol. 5, No. 4, 1996, p. 313-322.

Research output: Contribution to journalArticle

Dunn, JP, Noorily, SW, Petri, M, Finkelstein, D, Rosenbaum, JJ & Jabs, DA 1996, 'Antiphospholipid antibodies and retinal vascular disease', Lupus, vol. 5, no. 4, pp. 313-322.
Dunn JP, Noorily SW, Petri M, Finkelstein D, Rosenbaum JJ, Jabs DA. Antiphospholipid antibodies and retinal vascular disease. Lupus. 1996;5(4):313-322.
Dunn, James P. ; Noorily, S. W. ; Petri, M. ; Finkelstein, D. ; Rosenbaum, James (Jim) ; Jabs, D. A. / Antiphospholipid antibodies and retinal vascular disease. In: Lupus. 1996 ; Vol. 5, No. 4. pp. 313-322.
@article{68f714ae2c424f4dbfe5afbae989ae5a,
title = "Antiphospholipid antibodies and retinal vascular disease",
abstract = "Background. Antiphospholipid antibody retinopathy is a rare and poorly defined clinical entity in which the proper diagnosis has important ocular and systemic implications. The clinical course of five patients with antiphospholipid antibody retinopathy is described and the role of such antibodies in idiopathic retinal venous occlusive disease is investigated. Methods. Five case reports are presented highlighting the presentation, course, therapy, associations and outcomes of patients with antiphospholipid antibody retinopathy. In addition, twenty additional patients presenting with idiopathic retinal venous occlusive disease were tested for the presence of antiphospholipid antibodies. Results. All five patients with antiphospholipid antibody retinopathy had diffuse retinal vascular occlusion. All five patients presented with associated rheumatologic disease, including three with lupus or lupus-like disease. Antibodies to antiphospholipid were not detected in any of the twenty patients with idiopathic retinal venous occlusive disease. Prompt pan-retinal photocoagulation together with varying regimens of corticosteroids, immunosuppressives, or warfarin was partially successful in stabilizing the ocular and systemic disease. Conclusion. The diagnosis of antiphospholipid antibody retinopathy should be suspected in patients with diffuse retinal vaso-occlusion, particularly when characterized by involvement of both arteries and veins, neovascularization at presentation, and symptoms of systemic rheumatologic disease. Antiphospholipid antibodies do not appear to play an important role in idiopathic retinal vein occlusions.",
keywords = "Antiphospholipid antibody, Lupus anticoagulant, Retinal neovascularization, Retinal vein occlusion, Systemic lupus erythematosus",
author = "Dunn, {James P.} and Noorily, {S. W.} and M. Petri and D. Finkelstein and Rosenbaum, {James (Jim)} and Jabs, {D. A.}",
year = "1996",
language = "English (US)",
volume = "5",
pages = "313--322",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Antiphospholipid antibodies and retinal vascular disease

AU - Dunn, James P.

AU - Noorily, S. W.

AU - Petri, M.

AU - Finkelstein, D.

AU - Rosenbaum, James (Jim)

AU - Jabs, D. A.

PY - 1996

Y1 - 1996

N2 - Background. Antiphospholipid antibody retinopathy is a rare and poorly defined clinical entity in which the proper diagnosis has important ocular and systemic implications. The clinical course of five patients with antiphospholipid antibody retinopathy is described and the role of such antibodies in idiopathic retinal venous occlusive disease is investigated. Methods. Five case reports are presented highlighting the presentation, course, therapy, associations and outcomes of patients with antiphospholipid antibody retinopathy. In addition, twenty additional patients presenting with idiopathic retinal venous occlusive disease were tested for the presence of antiphospholipid antibodies. Results. All five patients with antiphospholipid antibody retinopathy had diffuse retinal vascular occlusion. All five patients presented with associated rheumatologic disease, including three with lupus or lupus-like disease. Antibodies to antiphospholipid were not detected in any of the twenty patients with idiopathic retinal venous occlusive disease. Prompt pan-retinal photocoagulation together with varying regimens of corticosteroids, immunosuppressives, or warfarin was partially successful in stabilizing the ocular and systemic disease. Conclusion. The diagnosis of antiphospholipid antibody retinopathy should be suspected in patients with diffuse retinal vaso-occlusion, particularly when characterized by involvement of both arteries and veins, neovascularization at presentation, and symptoms of systemic rheumatologic disease. Antiphospholipid antibodies do not appear to play an important role in idiopathic retinal vein occlusions.

AB - Background. Antiphospholipid antibody retinopathy is a rare and poorly defined clinical entity in which the proper diagnosis has important ocular and systemic implications. The clinical course of five patients with antiphospholipid antibody retinopathy is described and the role of such antibodies in idiopathic retinal venous occlusive disease is investigated. Methods. Five case reports are presented highlighting the presentation, course, therapy, associations and outcomes of patients with antiphospholipid antibody retinopathy. In addition, twenty additional patients presenting with idiopathic retinal venous occlusive disease were tested for the presence of antiphospholipid antibodies. Results. All five patients with antiphospholipid antibody retinopathy had diffuse retinal vascular occlusion. All five patients presented with associated rheumatologic disease, including three with lupus or lupus-like disease. Antibodies to antiphospholipid were not detected in any of the twenty patients with idiopathic retinal venous occlusive disease. Prompt pan-retinal photocoagulation together with varying regimens of corticosteroids, immunosuppressives, or warfarin was partially successful in stabilizing the ocular and systemic disease. Conclusion. The diagnosis of antiphospholipid antibody retinopathy should be suspected in patients with diffuse retinal vaso-occlusion, particularly when characterized by involvement of both arteries and veins, neovascularization at presentation, and symptoms of systemic rheumatologic disease. Antiphospholipid antibodies do not appear to play an important role in idiopathic retinal vein occlusions.

KW - Antiphospholipid antibody

KW - Lupus anticoagulant

KW - Retinal neovascularization

KW - Retinal vein occlusion

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=0029790534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029790534&partnerID=8YFLogxK

M3 - Article

C2 - 8869905

AN - SCOPUS:0029790534

VL - 5

SP - 313

EP - 322

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 4

ER -